Cucurbit [8] uril-based supramolecular fluorescent biomaterials for cytotoxicity and imaging studies of kidney cells

作者全名："Xiao, Han; Yang, Xia; Yang, Li; Yang, Dan; Luo, Yang; Yang, Hai-Ping; Tao, Zhu; Xiao, Xin; Li, Qiu"

作者地址："[Xiao, Han; Yang, Xia; Yang, Li; Yang, Hai-Ping; Li, Qiu] Chongqing Med Univ, Minist Educ Key Lab Child Dev & Disorders, Natl Clin Res Ctr Child Hlth & Disorders, Childrens Hosp,Dept Nephrol,Chongqing, Chongqing, Peoples R China; [Yang, Dan; Luo, Yang; Tao, Zhu; Xiao, Xin] Guizhou Univ, Inst Appl Chem, Key Lab Macrocycl & Supramol Chem Guizhou Prov, Guiyang, Peoples R China"

通信作者："Yang, HP; Li, Q (通讯作者)，Chongqing Med Univ, Minist Educ Key Lab Child Dev & Disorders, Natl Clin Res Ctr Child Hlth & Disorders, Childrens Hosp,Dept Nephrol,Chongqing, Chongqing, Peoples R China."

来源：FRONTIERS IN CHEMISTRY

ESI学科分类：CHEMISTRY

WOS号：WOS:000856590200001

JCR分区：Q2

影响因子：5.5

年份：2022

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：acute kidney injury; supramolecular fluorescent biomaterials; excellent fluorescence properties; low biological toxicity; macrocyclic host

摘要："An accurate diagnosis of acute kidney injury (AKI) at the early stage is critical to not only allow preventative treatments in time but also forecast probable medication toxicity for preventing AKI from starting and progressing to severe kidney damage and death. Therefore, supramolecular fluorescent biomaterials based on Q [8] and PEG-APTS have been prepared herein. This study has found that the unique properties of outer surface methine and the positive density of Q [8] can form a stable assembly with PEG-APTS, and has provided the possibility for the faster crossing of the glomerular filtration barrier to enter into the resident cells of the kidney. In addition to the excellent fluorescence properties, the as-synthesized biomaterial Q [8]@PEG-APTS has possessed significantly low biological toxicity. Most importantly, the accumulation of Q [8]@PEG-APTS in large amounts in cytoplasm and nucleus of HK2 and HMCs cells, respectively, within 24 h enabled distinguishing kidney cells when diagnosing and providing some foundation for early AKI."

基金机构："National Natural Science Foundation of China (NSFC) [81970618, 82170720]; Science and Technology Research Project of Chongqing Education Commission [KJZD-M201900401]; Program for Youth Innovation in Future Medicine, Chongqing Medical University [W0098]; Innovation Program for High-level Talents of Guizhou Province [20165657]"

基金资助正文："We thank the National Natural Science Foundation of China (NSFC no. 81970618 and 82170720), Science and Technology Research Project of Chongqing Education Commission (Grant no. KJZD-M201900401), Program for Youth Innovation in Future Medicine, Chongqing Medical University (no. W0098) and the Innovation Program for High-level Talents of Guizhou Province (no. 20165657) are gratefully acknowledged for financial support."