Association between blood lead levels and hyperlipidemiais: Results from the NHANES (1999-2018)

作者全名："Zhang, Yangchang; Liu, Weiwei; Zhang, Wei; Cheng, Rui; Tan, Andi; Shen, Shisi; Xiong, Yang; Zhao, Limei; Lei, Xun"

作者地址："[Zhang, Yangchang; Liu, Weiwei; Lei, Xun] Chongqing Med Univ, Sch Publ Hlth, Chongqing, Peoples R China; [Zhang, Yangchang; Lei, Xun] Chongqing Med Univ, Res Ctr Med & Social Dev, Chongqing, Peoples R China; [Zhang, Yangchang; Lei, Xun] Chongqing Med Univ, Innovat Ctr Social Risk Governance Hlth, Chongqing, Peoples R China; [Zhang, Yangchang; Lei, Xun] Chongqing Med Univ, Res Ctr Publ Hlth Secur, Chongqing, Peoples R China; [Liu, Weiwei; Zhang, Wei] Chongqing Coll Tradit Chinese Med, Chongqing, Peoples R China; [Liu, Weiwei] Res Ctr Med & Social Dev, Chongqing, Peoples R China; [Cheng, Rui] Nanchang Univ, Sch Publ Hlth, Jiangxi Prov Key Lab Prevent Med, Nanchang, Peoples R China; [Tan, Andi] Yunnan Univ Finance & Econ, Int Business Sch, Kunming, Peoples R China; [Shen, Shisi] Chongqing Med Univ, Sch Clin Med 1, Chongqing, Peoples R China; [Xiong, Yang] Sichuan Univ, West China Hosp, Chengdu, Peoples R China; [Zhao, Limei] Chongqing Jiangjin Cent Hosp, Chongqing, Peoples R China"

通信作者："Lei, X (通讯作者)，Chongqing Med Univ, Sch Publ Hlth, Chongqing, Peoples R China.; Lei, X (通讯作者)，Chongqing Med Univ, Res Ctr Med & Social Dev, Chongqing, Peoples R China.; Lei, X (通讯作者)，Chongqing Med Univ, Innovat Ctr Social Risk Governance Hlth, Chongqing, Peoples R China.; Lei, X (通讯作者)，Chongqing Med Univ, Res Ctr Publ Hlth Secur, Chongqing, Peoples R China."

来源：FRONTIERS IN PUBLIC HEALTH

ESI学科分类：SOCIAL SCIENCES, GENERAL

WOS号：WOS:000858999300001

JCR分区：Q1

影响因子：5.2

年份：2022

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：blood; lead; hyperlipidemia; NHANES; environment pollution; adults

摘要："BackgroundResearch on the association between blood lead (Pb) and lipid biomarkers have yielded inconsistent results, and epidemiological studies on blood Pb levels and hyperlipidemia are scarce. The present study aimed to examine the association between blood Pb levels and hyperlipidemia in adults from the National Health and Nutrition Examination Survey (NHANES). MethodsA total of 43,196 participants in the NHANES from 1999 to 2018 were included in the final analysis. Hyperlipidemia was determined based on the National Cholesterol Education Program guidelines. Blood Pb levels were assessed using inductively-coupled plasma mass spectrometry. Weighted multivariable logistic regression analysis and subgroup analysis were conducted to determine the correlation between blood Pb levels and hyperlipidemia. ResultsIn the multivariable logistic regression model, high blood Pb levels were significantly associated with hyperlipidemia after adjusting for confounders (OR 1.41; 95%CI: 1.18-1.67). Furthermore, elevated blood Pb levels were associated with an increased risk of hyperlipidemia across the four quartile (Q) groups (Q1: OR 1.00; Q2: OR 1.16 [95%CI: 1.04-1.29]; Q3: OR 1.39 [95%CI: 1.21-1.59]; and Q4: OR 1.33 [95%CI: 1.15-1.54]; P for trend <0.05). Significant moderating effects were found in the subgroup analysis stratified by age, education, hypertension, and diabetes (P < 0.05). In sensitivity analysis, the ORs for hyperlipidemia across the quartiles of blood Pb levels were 1.00, 1.17 (95%CI: 1.05-1.30), 1.42 (95%CI: 1.24-1.62), and 1.38 (95%CI: 1.19-1.60) for Q1, Q2, Q3, and Q4, respectively (P for trend <0.001) after removing adults with arteriosclerotic cardiovascular disease, and the ORs were 1.00, 1.13 (95%CI: 1.01-1.25), 1.38 (95%CI: 1.21-1.56), and 1.32 (95%CI: 1.16-1.52) for Q1, Q2, Q3, and Q4, respectively (P for trend <0.001) after including pregnant women. ConclusionThe current study showed a positive association between blood lead levels and hyperlipidemia."

基金机构：National Natural Science Foundation of China; Science and Technology Research Project of Chongqing Education Commission [72174033]; [KJQN202100432]

基金资助正文：This work was supported by the National Natural Science Foundation of China (No. 72174033) and the Science and Technology Research Project of Chongqing Education Commission (No. KJQN202100432).