Local Immunoglobulin E in nasal polyps: Role and modulation

作者全名："Shen, Yang; Zhang, Nan; Yang, Yucheng; Hong, Suling; Bachert, Claus"

作者地址："[Shen, Yang; Yang, Yucheng; Hong, Suling] Chongqing Med Univ, Dept Otorhinolaryngol, Affiliated Hosp 1, Chongqing, Peoples R China; [Zhang, Nan; Bachert, Claus] Univ Ghent, Dept Otorhinolaryngol, Upper Airways Res Lab, Ghent, Belgium; [Bachert, Claus] Karolinska Inst, Dept Clin Sci, Div Otorhinolaryngol Dis, Intervent & Technol CLINTEC, Stockholm, Sweden"

通信作者："Bachert, C (通讯作者)，Univ Ghent, Dept Otorhinolaryngol, Upper Airways Res Lab, Ghent, Belgium.; Bachert, C (通讯作者)，Karolinska Inst, Dept Clin Sci, Div Otorhinolaryngol Dis, Intervent & Technol CLINTEC, Stockholm, Sweden."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000860141200001

JCR分区：Q1

影响因子：7.3

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：Immunoglobulin E; local B cell; nasal polyposis; Type2 inflammation; Staphylococcus aureus

摘要："In the airway, IgE is traditionally regarded as a key mediator in allergic diseases, such as AR and allergic asthma. However, growing evidence demonstrates the importance of local IgE in airway inflammatory diseases, irrespective of the presence of allergy. In this review, we discuss the most recent evidence for IgE in chronic rhinosinusitis with nasal polyps(CRSwNP), including the local IgE's characteristics, the modulation of its synthesis, and its function. The levels of local IgE are significantly elevated in polyps independently of IgE serum levels and atopic status. Local IgE, which is correlated with type 2 inflammation, is polyclonal and functional. IgE is produced by active B cells and is dependent on the class switch recombination(CSR). In NPs, this process is triggered by not only allergens but also microbial colonization, especially the superantigen- Staphylococcus aureus. The production of local IgE is modulated by lymphocytes(such as Tfh, ILC2s, iTreg), cytokines(such as IL-4, IL-13, IFN-gamma, TGF-beta, IL-2, IL-21), transcription factors, and B cell-intrinsic factor. Due to the central role of IgE in NPs, it is regarded as an ideal target for therapy and has been proved to be clinically successful. Based on this knowledge, we believe that exploring the trigger and regulatory factors for the activation of local B cells and CSR to IgE will provide more valuable information for us to recognize the pathological mechanisms of local IgE and offer the possible option for new therapeutic targets of nasal polyps."

基金机构：National Natural Science Foundation of China [81970864]; Chongqing Talents Project [cstc2021ycjh-bgzxm0080]; Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) [2020MSXM035]

基金资助正文："This study was supported by National Natural Science Foundation of China, Grant/Award Number: 81970864; Chongqing Talents Project, Grant/Award Number: cstc2021ycjh-bgzxm0080; Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) (2020MSXM035)."