Semiquantitative assessment of Tc-99m-MIBI uptake in parathyroids of secondary hyperparathyroidism patients with chronic renal failure

作者全名："Yu, Dafu; Zou, Lin; Jin, Yao; Wei, Mingxiang; Wu, Xiaoqun; Zuo, Lingjing; Wu, Mingkang; Jiang, Yong"

作者地址："[Yu, Dafu] Sun Yat Sen Univ, Affiliated Hosp 8, Dept Nucl Med, Shenzhen, Peoples R China; [Yu, Dafu; Jin, Yao; Wei, Mingxiang; Zuo, Lingjing; Wu, Mingkang; Jiang, Yong] First Peoples Hosp Yunnan Prov, Dept Nucl Med, Kunming, Peoples R China; [Zou, Lin] Chongqing Med Univ, Affiliated Hosp 1, Dept Lab Med, Chongqing, Peoples R China; [Wu, Xiaoqun] First Peoples Hosp Yunnan Prov, Dept Resp Dis, Kunming, Peoples R China"

通信作者："Yu, DF (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 8, Dept Nucl Med, Shenzhen, Peoples R China.; Yu, DF; Jiang, Y (通讯作者)，First Peoples Hosp Yunnan Prov, Dept Nucl Med, Kunming, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000860144500001

JCR分区：Q2

影响因子：5.2

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：secondary hyperparathyroidism; semiquantitative assessment; chronic renal failure; parathyroids; Tc-99m-methoxyisobutylisonitrile (MIBI)

摘要："ObjectiveTo explore the valuably influential factors and improve the diagnostic accuracy and efficiency of Tc-99m-methoxyisobutylisonitrile (MIBI) uptake in parathyroids of secondary hyperparathyroidism (SHPT) patients with chronic renal failure (CRF). MethodsThe correlation analysis was performed between clinical indices related to CRF and Tc-99m-MIBI uptake intensity TBR (the gray value mean ratio between the parathyroid target and the bilateral neck background, semiquantitatively calculated with ImageJ software). All clinical indices and TBRs were compared by a three- or two-level grouping method of MIBI uptake, which was visually qualitatively assessed. The three-level grouping method comprised slight, medium, and high groups with little, faint, and distinct MIBI concentration in parathyroids, respectively. The two-level grouping method comprised insignificant and significant groups with TBR greater than or less than 0.49-0.71, respectively. ResultsMIBI uptake was significantly positively related to patient age, CRF course, hemodialysis vintage, serum parathyroid hormone (PTH), and alkaline phosphatase (AKP) but was significantly negatively related to serum uric acid (UA). MIBI washout was significantly positively related to patient age but was significantly negatively related to serum phosphorus (P) and calcium (Ca) x P. Oral administration of calcitriol and calcium could significantly reduce the MIBI uptake. MIBI uptake tendency might alter. Such seven indices, namely the MIBI uptake, CRF course, hemodialysis vintage, serum AKP, calcium, cysteine proteinase inhibitor C, and PTH, were comparable between the slight and medium groups but were significantly different between the slight and high groups or between the medium and high groups. The above seven indices plus blood urea nitrogen/creatinine were all significantly different between the insignificant and significant groups. All above significances were with P < 0.05. ConclusionsPatient age, CRF course, hemodialysis vintage, serum PTH, AKP, UA, phosphorus, Ca x P, oral administration of calcitriol and calcium, and parathyroids themselves can significantly influence MIBI uptake in parathyroids of SHPT patients with CRF. The two-level grouping method of MIBI intensity should be adopted to qualitatively diagnose the MIBI uptake."

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