Cuprotosis-Related Genes: Predicting Prognosis and Immunotherapy Sensitivity in Pancreatic Cancer Patients

作者全名："Xu, Yingkun; Li, Han; Lan, Ailin; Wu, Qiulin; Tang, Zhenrong; Shu, Dan; Tan, Zhaofu; Liu, Xin; Liu, Yang; Liu, Shengchun"

作者地址："[Xu, Yingkun; Li, Han; Lan, Ailin; Wu, Qiulin; Tang, Zhenrong; Shu, Dan; Tan, Zhaofu; Liu, Xin; Liu, Yang; Liu, Shengchun] Chongqing Med Univ, Dept Breast & Thyroid Surg, Affiliated Hosp 1, Chongqing 400042, Peoples R China"

通信作者："Liu, SC (通讯作者)，Chongqing Med Univ, Dept Breast & Thyroid Surg, Affiliated Hosp 1, Chongqing 400042, Peoples R China."

来源：JOURNAL OF ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000860646800001

JCR分区：Q2

影响因子：4.501

年份：2022

卷号：2022

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Based on TCGA, GTEx, and TIMER databases and various bioinformatics analysis methods, the potential biological roles of cuprotosis-related genes in pancreatic cancer were deeply explored, and a predictive model for pancreatic cancer patients was constructed. We downloaded the RNA-Seq data and clinicopathological and predictive data of 179 pancreatic cancer tissues and 332 adjacent normal tissues from TCGA and GTEx databases. The differential expression of cuprotosis-related genes in pancreatic cancer tissue and adjacent normal tissue was analyzed, and the LASSO regression algorithm was used to construct a prediction model and verify the validity of the model prediction. Based on the LASSO regression algorithm, a predictive model composed of three genes LIPT1, LIAS, and DLAT was screened. The corresponding survival curves showed that the constructed prediction model could significantly distinguish the prognosis of pancreatic cancer patients, and the prognosis of patients in the high-risk group was worse (P = 0.00557). The ROC curve showed that the area under the curve of the predictive model for predicting the 4-, 5-, and 6-year survival rates in pancreatic cancer was 0.816, 0.836, and 0.956, respectively. The AUC value of this risk model was significantly higher than 0.7, which could more accurately predict the prognosis of pancreatic cancer patients. This study determined a risk-scoring model of cuprotosis-related genes, which can provide an essential basis for judging the prognosis of pancreatic cancer patients."

基金机构：National Natural Science Foundation of China; Key Research and Development Project of Chongqing's Technology Innovation and Application Development Special Big Health Field; Doctoral Research Innovation Project of the First Affiliated Hospital of Chongqing Medical University; [81772979]; [CSTC2021jscx-gksb-N0027]; [CYYY-BSYJSCXXM-202213]

基金资助正文："AcknowledgmentsThis research was funded by the National Natural Science Foundation of China (Grant no. 81772979), the Key Research and Development Project of Chongqing's Technology Innovation and Application Development Special Big Health Field (Grant no. CSTC2021jscx-gksb-N0027), and the Doctoral Research Innovation Project of the First Affiliated Hospital of Chongqing Medical University (Grant no. CYYY-BSYJSCXXM-202213)."