NF-kappa B: A novel therapeutic pathway for gastroesophageal reflux disease?

作者全名："Zhang, Mao-Lin; Ran, Long-Qing; Wu, Meng-Jun; Jia, Qin-Chen; Qin, Zhi-Ming; Peng, Yong G."

作者地址："[Zhang, Mao-Lin; Qin, Zhi-Ming] Chongqing Med Univ, Affiliated Hosp 1, Dept Thorac & Cardiovasc Surg, Chongqing 400042, Peoples R China; [Ran, Long-Qing; Wu, Meng-Jun] Univ Elect Sci & Technol China, Chengdu Womens & Childrens Cent Hosp, Sch Med, Dept Anesthesia, Chengdu 610019, Peoples R China; [Jia, Qin-Chen] Chongqing Med Univ, Affiliated Hosp 1, Thorac & Cardiovasc Surg, Chongqing 400042, Peoples R China; [Peng, Yong G.] Univ Florida, Coll Med, Dept Anesthesiol, Gainesville, FL 32610 USA; [Qin, Zhi-Ming] Chongqing Med Univ, Affiliated Hosp 1, Dept Thorac & Cardiovasc Surg, 1 Youyi Rd, Chongqing 400042, Peoples R China"

通信作者："Qin, ZM (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Thorac & Cardiovasc Surg, 1 Youyi Rd, Chongqing 400042, Peoples R China."

来源：WORLD JOURNAL OF CLINICAL CASES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000863262300002

JCR分区：Q3

影响因子：1.1

年份：2022

卷号：10

期号：24

开始页：8436

结束页：8442

文献类型：Review

关键词：Gastroesophageal reflux disease; NF-kappa B; Pathogenesis; Mechanism; Inflammatory injury; Esophageal epithelial barrier

摘要："Although gastroesophageal reflux disease (GERD), a common chronic disease in clinical practice, has been widely studied, its potential adverse impact on patients is still a significant clinical concern. It is necessary to understand the pathogenesis of the disease and choose appropriate treatment according to its mechanism. The pathogenesis of GERD is diverse and complex. As the traditional treatment methods are expensive and ineffective in alleviating symptoms in some patients, new treatment options need to be explored. Our previous study suggested that the activation of nuclear factor-kappa beta (NF-kappa B) in esophageal mucosa may be related to the injury of epithelial barrier function caused by reflux. Based on the literature and our previous study results, it is speculated that inhibition of NF-kappa B activation may block the insult of GERD on the esophageal mucosal barrier. NF-kappa B may play an important role in the development of GERD. This article reviews the pathogenesis of GERD and the relationship between NF-kappa B and GERD, in order to provide new strategies for the treatment of GERD."

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