Metastasis of a basosquamous carcinoma arising in a nevus sebaceus

作者全名："Ye, Qian; Shen, Xiao; Wang, Jie; Li, Feng-Zeng; Fang, Sheng"

作者地址："[Ye, Qian; Li, Feng-Zeng; Fang, Sheng] Chongqing Med Univ, Dept Dermatol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Shen, Xiao] Chongqing Med Univ, Dept Plast & Burn Surg, Affiliated Hosp 1, Chongqing, Peoples R China; [Wang, Jie] Chongqing Med Univ, Dept Nucl Med, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Fang, S (通讯作者)，Chongqing Med Univ, Dept Dermatol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：JOURNAL OF CUTANEOUS PATHOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000863740400001

JCR分区：Q3

影响因子：1.7

年份：2022

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期号：　

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文献类型：Article; Early Access

关键词：basal cell carcinoma; malignant; metastasis; sebaceous nevus

摘要："Nevus sebaceus (NS) is a congenital hamartoma of skin structures including the epidermis, sweat sebaceous glands, and hair follicles. It is known that secondary tumors can occur in NS. However, secondary metastatic malignancies are rare. Basosquamous carcinoma (BSC) is an aggressive type of basal cell carcinoma (BCC) characterized by squamous differentiation. Herein, we report a case of metastatic BSC that developed in a 73-year-old male with NS. The clinical presentation of this patient was that of an ulcerative nodule developing in a longstanding plaque-like lesion consistent with NS. Histopathological examination revealed characteristic features of BCC with some areas of squamous differentiation in addition to the structure of a typical NS. Immunohistochemical expression of Ber-EP4, AE1/AE3, and epithelial membrane antigen helped to make the diagnosis of BSC."

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