Identification and Exploration of Serine Peptidase Inhibitor Kazal Type I (SPINK1) as a Potential Biomarker Correlated with the Progression of Non-Small Cell Lung Cancer

作者全名："Li, Dingyi; Zhang, Xinxin; Ding, Zhiqiang; Ai, Rongshuang; Shi, Luyao; Wang, Zimeng; He, Qian; Dong, Yilin; Zhu, Yiting; Ouyang, Wenzhong; He, Yujuan"

作者地址："[Li, Dingyi; Zhang, Xinxin; Ai, Rongshuang; Shi, Luyao; He, Qian; Dong, Yilin; Zhu, Yiting; He, Yujuan] Chongqing Med Univ, Dept Lab Med, Key Lab Diagnost Med, Minist Educ, Chongqing, Peoples R China; [Zhang, Xinxin] Shandong Univ Qingdao, Dept Lab Med, Qilu Hosp, Qingdao, Shandong, Peoples R China; [Ding, Zhiqiang] Chongqing Inst Engn, Sch Comp Sci, Chongqing, Peoples R China; [Wang, Zimeng] Chongqing Hosp Tradit Chinese Med, Dept Lab Med, Chongqing, Peoples R China; [He, Qian] First Peoples Hosp Longquanyi Dist Chengdu, Dept Lab Med, Chengdu, Sichuan, Peoples R China; [Ouyang, Wenzhong] Chongqing Qiujing High Sch, Chongqing, Peoples R China"

通信作者："He, YJ (通讯作者)，Chongqing Med Univ, Dept Lab Med, Key Lab Diagnost Med, Minist Educ, Chongqing, Peoples R China."

来源：CELL BIOCHEMISTRY AND BIOPHYSICS

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000863810500001

JCR分区：Q3

影响因子：2.6

年份：2022

卷号：80

期号：4

开始页：807

结束页：818

文献类型：Article

关键词：SPINK1; NSCLC; Proliferation; Signaling pathway

摘要："Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Although significant advances have been achieved in the treatment of NSCLC during the past two decades, the 5-year survival rate of patients with NSCLC remains <20%. Thus, there is an urgent requirement to further understand the molecular mechanisms that promote NSCLC development and to identify novel therapeutic targets. In the present study, the gene expression profiles of patients with NSCLC from The Cancer Genome Atlas database were carefully analyzed and SPINK1 was identified as a tumor-inducing factor. SPINK1 expression level was found to be increased in both NSCLC tissues and cell lines. Moreover, SPINK1 promoted cell proliferation in A549 and H1299 cells. Knockdown of SPINK1 could activate cell autophagy and apoptosis. Mechanistically, SPINK1 was demonstrated to induce the proliferation of NSCLC via activating the MEK/ERK signaling pathway. In conclusion, these findings suggested that SPINK1 may serve as a potential biomarker in NSCLC."

基金机构：National Natural Science Foundation grants of China [csfc81373151]; Natural Science Foundation Project of CQCSTC [cstc2018jcyjAX0257]

基金资助正文：This study is supported by National Natural Science Foundation grants of China (No. csfc81373151) and Natural Science Foundation Project of CQCSTC (No. cstc2018jcyjAX0257). We thank Zhiqiang Ding for the correction of the English usage of the manuscript.