"Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options"

作者全名："Liu, Di; Huang, Si-Yuan; Sun, Jian-Hui; Zhang, Hua-Cai; Cai, Qing-Li; Gao, Chu; Li, Li; Cao, Ju; Xu, Fang; Zhou, Yong; Guan, Cha-Xiang; Jin, Sheng-Wei; Deng, Jin; Fang, Xiang-Ming; Jiang, Jian-Xin; Zeng, Ling"

作者地址："[Liu, Di; Huang, Si-Yuan; Sun, Jian-Hui; Zhang, Hua-Cai; Cai, Qing-Li; Gao, Chu; Jiang, Jian-Xin; Zeng, Ling] Army Med Univ, Daping Hosp, Dept Trauma, State Key Lab Trauma,Med Ctr, Chongqing 400042, Peoples R China; [Li, Li] Army Med Univ, Daping Hosp, Dept Resp Dis, Chongqing 400042, Peoples R China; [Cao, Ju] Chongqing Med Univ, Dept Lab Med, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Xu, Fang] Chongqing Med Univ, Dept Crit Care Med, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Zhou, Yong; Guan, Cha-Xiang] Cent South Univ, Sch Basic Med Sci, Dept Physiol, Changsha 410078, Peoples R China; [Jin, Sheng-Wei] Wenzhou Med Univ, Dept Anesthesia & Crit Care, Affiliated Hosp 2, Wenzhou 325027, Zhejiang, Peoples R China; [Jin, Sheng-Wei] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Zhejiang, Peoples R China; [Deng, Jin] Guizhou Med Univ, Affiliated Hosp, Dept Emergency, Guiyang 550001, Peoples R China; [Fang, Xiang-Ming] Zhejiang Univ, Affiliated Hosp 1, Dept Anesthesiol, Sch Med, Hangzhou 310052, Peoples R China"

通信作者："Jiang, JX; Zeng, L (通讯作者)，Army Med Univ, Daping Hosp, Dept Trauma, State Key Lab Trauma,Med Ctr, Chongqing 400042, Peoples R China.; Fang, XM (通讯作者)，Zhejiang Univ, Affiliated Hosp 1, Dept Anesthesiol, Sch Med, Hangzhou 310052, Peoples R China."

来源：MILITARY MEDICAL RESEARCH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000865178900001

JCR分区：Q1

影响因子：21.1

年份：2022

卷号：9

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Sepsis; Immunosuppression; Immune monitoring; Immunomodulatory therapy

摘要："Sepsis is a common complication of combat injuries and trauma, and is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. It is also one of the significant causes of death and increased health care costs in modern intensive care units. The use of antibiotics, fluid resuscitation, and organ support therapy have limited prognostic impact in patients with sepsis. Although its pathophysiology remains elusive, immunosuppression is now recognized as one of the major causes of septic death. Sepsis-induced immunosuppression is resulted from disruption of immune homeostasis. It is characterized by the release of anti-inflammatory cytokines, abnormal death of immune effector cells, hyperproliferation of immune suppressor cells, and expression of immune checkpoints. By targeting immunosuppression, especially with immune checkpoint inhibitors, preclinical studies have demonstrated the reversal of immunocyte dysfunctions and established host resistance. Here, we comprehensively discuss recent findings on the mechanisms, regulation and biomarkers of sepsis-induced immunosuppression and highlight their implications for developing effective strategies to treat patients with septic shock."

基金机构："National Natural Science Foundation of China [82222038, 82020108021, 82260372]; Chongqing Special Project for Academicians [cstc2020yszx-jcyjX0004]; Science Foundation for Outstanding Youth of the Army Medical Centre [2019CXJSB004]; Chongqing Outstanding Youth Foundation"

基金资助正文："This study was supported by the National Natural Science Foundation of China (82222038, 82020108021 and 82260372), the Chongqing Special Project for Academicians (cstc2020yszx-jcyjX0004), Chongqing Outstanding Youth Foundation and Science Foundation for Outstanding Youth of the Army Medical Centre (2019CXJSB004)."