3D island sign on computed tomography predicts early perihematomal edema expansion and poor outcome in patients with intracerebral hemorrhage

作者全名："Li, Yu-Lun; Zhao, Rui; Zheng, Yi-Neng; Wei, Miao; Li, Zuo-Qiao; Hu, Xiao; Li, Qi; Lv, Fa-Jin"

作者地址："[Li, Yu-Lun; Zheng, Yi-Neng; Wei, Miao; Lv, Fa-Jin] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing 400016, Peoples R China; [Zhao, Rui] Chongqing Med Univ, Yongchuan Hosp, Dept Neurol, Chongqing 402160, Peoples R China; [Li, Zuo-Qiao; Hu, Xiao; Li, Qi] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China"

通信作者："Lv, FJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing 400016, Peoples R China.; Li, Q (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China."

来源：CLINICAL NEUROLOGY AND NEUROSURGERY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000867452200007

JCR分区：Q2

影响因子：1.9

年份：2022

卷号：222

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Brain edema; Cerebral hemorrhage; Prognosis; Tomography; X-ray computed

摘要："Background and purpose: To determine the prognostics significance of the computed tomography (CT) 3D island sign for predicting early perihematomal edema (PHE) expansion and poor functional outcome in patients pre-senting with intracerebral hemorrhage (ICH).Methods: Between July 2011 and March 2017, patients with intracerebral hemorrhage who had undergone baseline CT within 6 h after ICH symptom onsets and follow-up CT in our hospital were included. Two different readers independently assessed the presence of 3D island sign on admission CT scan of each patient. Multivar-iable logistic regression analysis was used to analyze association between 3D island sign and early peri-hematomal edema expansion and poor functional outcome, separately.Results: A total of 214 patients who met the inclusion criteria were included in our study, 3D island sign was observed in 60 patients (28.0 %) on admission CT scan. The multivariate logistic regression analysis demon-strated that baseline hematoma volume, time to baseline and follow-up CT scans and the presence of 3D island sign were predictors of early PHE expansion. After adjusting for age, baseline hematoma and edema volume, time to baseline and follow-up CT scans, GCS on admission, presence of intraventricular hemorrhage (IVH) and systolic blood pressure, the 3D island sign was an independently imaging marker for poor outcome (OR, 2.803; 95 % confidence interval, 1.189-6.609; P = 0.018).Conclusion: The 3D island sign in patients with intracerebral hemorrhage was a reliable predictor for early perihematomal edema expansion and poor functional outcome. It may serve as a potential therapeutic target for intervention."

基金机构：National Natural Science Foundation of China; Na-tional Key Research and Development Program of China; Chongqing High-end Young Investigator Project; [82071337]; [2018YFC1312200]; [2018YFC1312203]; [2019GDRC005]

基金资助正文："Acknowledgements National Natural Science Foundation of China (No. 82071337) , Na-tional Key Research and Development Program of China (No.2018YFC1312200, No.2018YFC1312203) , Chongqing High-end Young Investigator Project (No.2019GDRC005) ."