Swelling of Multilayered Calcium Alginate Microspheres for Drug-Loaded Dressing Induced Rapid Lidocaine Release for Better Pain Control
作者全名："Ma, Rong-Rong; Xu, Hui-Xian; Ni, Li; Xiong, Jia-Min; Chen, Yi-Lin; He, Jia-Yuan; Li, Qin; Yang, Li-Li; Zhou, Lian-Di; Zhang, Qi-Hui; Luo, Ling"
作者地址："[Ma, Rong-Rong; Xu, Hui-Xian; Ni, Li; Xiong, Jia-Min; Chen, Yi-Lin; He, Jia-Yuan; Li, Qin; Yang, Li-Li; Zhang, Qi-Hui] Chongqing Univ, Sch Chem & Chem Engn, Univ Town South Rd 55, Chongqing 400044, Peoples R China; [Zhou, Lian-Di] Chongqing Med Univ, Basic Med Coll, Univ Town Middle Rd 61, Chongqing 400016, Peoples R China; [Luo, Ling] Chongqing Univ Canc Hosp, Chongqing Canc Inst, Hanyu Rd 181, Chongqing 400030, Peoples R China"
通信作者："Zhang, QH (通讯作者)，Chongqing Univ, Sch Chem & Chem Engn, Univ Town South Rd 55, Chongqing 400044, Peoples R China.; Zhou, LD (通讯作者)，Chongqing Med Univ, Basic Med Coll, Univ Town Middle Rd 61, Chongqing 400016, Peoples R China.; Luo, L (通讯作者)，Chongqing Univ Canc Hosp, Chongqing Canc Inst, Hanyu Rd 181, Chongqing 400030, Peoples R China."
来源：AMERICAN JOURNAL OF CHINESE MEDICINE
文献类型：Article; Early Access
关键词：Drug Formulation; Compound Release; Analgesia; Blood Coagulation; Plant Compounds
摘要："The development of effective drug-loaded dressings has been considered a hot research topic for biomedical therapeutics, including the use of botanical compounds. For wound healing, adequate dressings can provide a good microenvironment for drug release, such as lidocaine. Biological macromolecular materials such as alginate show excellent properties in wound management. This study involves the preparation and evaluation of biocompatible multilayered-structure microspheres composed of chitosan, porous gelatin, and calcium alginate microspheres. The multilayered structure microspheres were named chitosan@ porous gelatin@ calcium alginate microspheres (CPAMs) and the drugs were rapidly released by the volume expansion of the calcium alginate microspheres. The in vitro release curve revealed that the peak release of lidocaine from CPAMs was reached within 18 min. After 21 min, the remaining lidocaine was then slowly released, and the active drug release was converted to a passive drug release phase. The initial release effect of lidocaine was much better than that reported in the published studies. Additionally, blood coagulation experiments showed that CPAMs coagulated blood in 60 s, and the blood liquidity of the CPAMs group was worse than that of the woundplast group. Therefore, the coagulation characteristics of CPAMs were superior to the commonly used woundplast containing lidocaine healing gel. These study outcomes indicated that the CPAMs acted as fast-release dressings for faster pain control and better coagulation properties."
基金机构："National Natural Science Foundation of China ; Fundamental and Frontier Research Fund of Chongqing [cstc2018jcy-jAX0661, cstc2019jsyj-yzysbAX0020]; Science and Technology Research Program of Chongqing Municipal Education Commission [KJZD-K201800103]; Fundamental Research Funds for the Central Universities [2019CDYGYB027, 2022CDJXY-003]; Graduate Research and Innovation Foundation of Chongqing [CYS18033]; Venture & Innovation Support Program for Chongqing Overseas Returnees"
基金资助正文："This work was financially supported by National Natural Science Foundation of China (81973451), Fundamental and Frontier Research Fund of Chongqing (cstc2018jcy-jAX0661, cstc2019jsyj-yzysbAX0020), the Science and Technology Research Program of Chongqing Municipal Education Commission (KJZD-K201800103), Fundamental Research Funds for the Central Universities (2019CDYGYB027, 2022CDJXY-003), Graduate Research and Innovation Foundation of Chongqing (CYS18033), Venture & Innovation Support Program for Chongqing Overseas Returnees."