Clinical Efficacy and Safety Analysis of Levofloxacin for the Prevention of Infection after Traumatic Osteoarthrosis and Internal Fixation: Systematic Review and Meta-Analysis

作者全名："Wang, Weiliang; Zou, ChuanQi; Zhang, Jie"

作者地址："[Wang, Weiliang] Beijing Daxing Dist Peoples Hosp, Dept Traumatol, Beijing 102600, Peoples R China; [Zou, ChuanQi] Chongqing Med Univ, Dept Orthoped, Banan Hosp, Chongqing 400000, Peoples R China; [Zhang, Jie] Nanchang Univ, Affiliated Hosp 1, Dept Pharm, Nanchang 330001, Jiangxi, Peoples R China"

通信作者："Zhang, J (通讯作者)，Nanchang Univ, Affiliated Hosp 1, Dept Pharm, Nanchang 330001, Jiangxi, Peoples R China."

来源：EMERGENCY MEDICINE INTERNATIONAL

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000868894300001

JCR分区：Q3

影响因子：1.2

年份：2022

卷号：2022

期号：　

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结束页：　

文献类型：Review

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摘要："Objective. Levofloxacin has been widely used in clinical anti-infection treatment; however, its adverse reactions to levofloxacin were also obvious in patients. Herein we aimed to systematically evaluate the clinical efficacy and safety of systemic administration of levofloxacin in the prevention of postoperative infection after traumatic osteoarthrosis and internal fixation. Methods. PubMed, Cochrane Library, OVID, EBSCO, CNKI, VIP database, and Wanfang Database were searched from December 1993 to December 2021. Meanwhile, China ADR Information Bulletin and WHO Pharmaceutical were searched manually. Newsletter and FDA Drug Safety Newsletter, also to retrieve the Websites of Chinese, Chinese, and drug regulatory authorities; To obtain data on adverse events in children with systemic administration of levofloxacin. The literature was screened according to inclusion and exclusion criteria. The risk of bias was evaluated for the included RCT literature. Results. There was a statistical difference in the comparison of the incidence of fever between the experimental group and the control group (OR = 2.29, 95% CI (1.75, 2.98), P < 0.00001, I-2 = 0%, Z = 6.11); elevated white blood cell count (OR = 1.82, 95% CI (1.31, 2.52), P=0.0003, I-2 = 0%, Z = 3.60); incidence of wound infection (OR = 2.11, 95% CI (1.54, 2.90), P < 0.00001, I-2 = 0%, Z = 4.64); adverse drug reaction (OR = 1.82, 95% CI (1.21, 2.74), P=0.004, I-2 = 0%, Z = 2.86). Conclusion. In the clinical use of levofloxacin, adverse drug reactions including fever, elevated white blood cell count, and wound infection should be concerned."

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