Renal fat fraction is significantly associated with the risk of chronic kidney disease in patients with type 2 diabetes

作者全名："Shen, Yan; Xie, Lianghua; Chen, Xiangjun; Mao, Lina; Qin, Yao; Lan, Rui; Yang, Shumin; Hu, Jinbo; Li, Xue; Ye, Hanwen; Luo, Wenjin; Gong, Lilin; Li, Qifu; Mao, Yun; Wang, Zhihong"

作者地址："[Shen, Yan; Chen, Xiangjun; Mao, Lina; Qin, Yao; Lan, Rui; Yang, Shumin; Hu, Jinbo; Li, Xue; Ye, Hanwen; Luo, Wenjin; Gong, Lilin; Li, Qifu; Wang, Zhihong] Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol, Chongqing, Peoples R China; [Xie, Lianghua; Mao, Yun] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China"

通信作者："Wang, ZH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol, Chongqing, Peoples R China.; Mao, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000869143500001

JCR分区：Q2

影响因子：5.2

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：renal fat fraction; chronic kidney disease; ectopic fat deposition; type 2 diabetes mellitus; magnetic resonance imaging

摘要："BackgroundsEctopic fat deposition is closely related to chronic kidney disease (CKD). Currently, there are few population studies that have been conducted to determine the relationship between renal parenchyma fat deposition and the risk of CKD among patients with type 2 diabetes mellitus (T2DM). Therefore, we employed magnetic resonance imaging (MRI) to detect renal parenchyma fat content in individuals with T2DM, expressed as renal fat fraction (FF), to explore whether renal FF is an important risk factor for CKD in patients with T2DM. MethodsIn this cross-sectional study, 189 subjects with T2DM were enrolled. CKD was defined as the estimated glomerular filtration rate (eGFR)<60 mL/min/1.73m(2). Measurement of the renal FF was performed on a 3.0-T MRI (MAGNETOM Skyra, Siemens, Erlangen, Germany). Binary logistic regression was used to determine the association between tertiles of renal FF and risk of CKD. Receiver-operator characteristic (ROC) curves were constructed to evaluate the sensitivity and specificity of renal FF in detecting CKD in T2DM patients. ResultsThe patients were divided into three groups according to tertiles of the renal FF level (2.498 - 7.434). As renal FF increases, patients tend to be older, and more abdominally obese, with a decreased eGFR (p<0.05). After adjustment for potential confounders, patients in the highest tertile of renal FF had a significantly increased risk of CKD than those in the lowest tertile (odds ratio (OR) = 3.98, 95% confidence interval (CI) = 1.12 - 14.09, p = 0.032), and the area under the ROC curve for this model was 0.836 (0.765-0.907). ConclusionsThe renal FF is significantly independently associated with CKD in patients with T2DM."

基金机构："Technological Innovation and Application Development Project of Chongqing [cstc2019jscx-msxmX0207]; Chongqing Science and Health Joint Medical Research Project [2020FYYX141, 2018GDRC004]; Innovative Funded Project of Chongqing Innovation and Retention Program [cx2019032]; National Natural Science Foundation of China [81870567]; Chongqing Yong and Middle-aged Senior Medical Talents Studio [ZQNYXGDRCGZS2021001]"

基金资助正文："This work was supported by the Technological Innovation and Application Development Project of Chongqing (cstc2019jscx-msxmX0207), the Chongqing Science and Health Joint Medical Research Project (2020FYYX141; 2018GDRC004), the Innovative Funded Project of Chongqing Innovation and Retention Program (cx2019032) and the Chongqing Yong and Middle-aged Senior Medical Talents Studio (ZQNYXGDRCGZS2021001) and the National Natural Science Foundation of China (81870567)."