A retrospective case series of electroconvulsive therapy in the management of depression and suicidal symptoms in adolescents

作者全名："Chen, Xiaolu; Fu, Yixiao; Zou, Qianhong; Zhang, Yiting; Qin, Xiaoyue; Tian, Yu; Yan, Yu; Chen, Qibin; Zou, Lei; Zhao, Bangshu; Li, Xiao"

作者地址："[Chen, Xiaolu] Chongqing Med Univ, Branch 1, Affiliated Hosp 1, Chongqing, Peoples R China; [Fu, Yixiao; Li, Xiao] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China; [Zou, Qianhong; Zhang, Yiting; Qin, Xiaoyue; Tian, Yu] Chongqing Med Univ, Dept Clin Med 1, Chongqing, Peoples R China; [Yan, Yu] Chongqing Med Univ, Informat Ctr, Affiliated Hosp 1, Chongqing, Peoples R China; [Chen, Qibin; Zou, Lei; Zhao, Bangshu] Chongqing Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Chongqing, Peoples R China"

通信作者："Li, X (通讯作者)，Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：BRAIN AND BEHAVIOR

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000869788200001

JCR分区：Q2

影响因子：3.1

年份：2022

卷号：12

期号：11

开始页：　

结束页：　

文献类型：Article

关键词：adolescents; depression; efficacy; electroconvulsive therapy (ECT); side effect; suicide

摘要："Objective Major depressive disorder (MDD) with suicidal symptoms is common in adolescents. Electroconvulsive therapy (ECT) is highly effective in the treatment of MDD. We have described its use and outcome in a case series of adolescents with depression and suicidal symptoms receiving ECT. Methods We analyzed 362 adolescents aged from 12 to 17 who had received ECT between year 2015 and 2021. A total of 278 subjects were found to meet the inclusion criteria, where depressive symptoms were assessed by HDRS and suicidal symptoms were assessed by HDRS item 3. Their sociodemographic, clinical, and treatment information were retrieved through these records for this study. Results The mean +/- SD age of subjects was 15.41 +/- 1.50 years and male sex was 14.7% (n = 41). Comorbid diagnoses were present in 104 patients (37.4%). The ECT sessions ranged from 6 to 12 times. All the patients took antidepressants, with sertraline (n = 182; 65.5%) being the most widely used. Majority of patients also received benzodiazepines. ECT was significantly effective in adolescents with depression and suicidal symptoms in evaluation by HDRS, HDRS item 3, CGI-S (p < .001) pre/post-ECT. The response rate of MDD patients was 52%, with suicidal ideation (SI) at 49%, and 54% in MDD with suicide attempt (SA). The change of CGI-S scores showed no significant differences between various subgroups of sex and comorbid (p>.05), but there were significant differences between subgroups of suicidal symptoms (p < .001). ECT was generally safe with subjective memory complaint (n = 189, 68.0%), headache (n = 150, 54.0%), body pain (n = 28, 10.1%), delirium (n = 95, 34.2%), and nausea (n = 31, 11.2%) as possible side effects following ECT. Conclusion In this study, ECT was found to decrease depressive and suicidal symptoms in adolescents, and the side effect was acceptable. ECT showed better outcome for MDD with SA compared to MDD with SI."

基金机构："Program for Youth Innovation in Future Medicine, Chongqing Medical University [w0107]; Chongqing Health Commission [2019MSXM045]; Chongqing Science and Technology Commission [2019MSXM045]"

基金资助正文："Program for Youth Innovation in Future Medicine, Chongqing Medical University, Grant/Award Number: w0107; Chongqing Health Commission and Chongqing Science and Technology Commission, Grant/Award Number: 2019MSXM045"