Endogenous Vasoactive Peptides and Vascular Aging-Related Diseases

作者全名："Chen, Yao; Qi, Yongfen; Lu, Weiwei"

作者地址："[Chen, Yao] Chongqing Med Univ, Sch Basic Med Sci, Dept Physiol, Chongqing 400016, Peoples R China; [Qi, Yongfen] Peking Univ, Minist Educ, Key Lab Mol Cardiovasc Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China; [Lu, Weiwei] Soochow Univ, Dept Physiol & Neurobiol, Med Coll, Suzhou 215123, Peoples R China"

通信作者："Qi, YF (通讯作者)，Peking Univ, Minist Educ, Key Lab Mol Cardiovasc Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China.; Lu, WW (通讯作者)，Soochow Univ, Dept Physiol & Neurobiol, Med Coll, Suzhou 215123, Peoples R China."

来源：OXIDATIVE MEDICINE AND CELLULAR LONGEVITY

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000869967200006

JCR分区：Q2

影响因子：7.31

年份：2022

卷号：2022

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：　

摘要："Vascular aging is a specific type of organic aging that plays a central role in the morbidity and mortality of cardiovascular and cerebrovascular diseases among the elderly. It is essential to develop novel interventions to prevent/delay age-related vascular pathologies by targeting fundamental cellular and molecular aging processes. Endogenous vasoactive peptides are compounds formed by a group of amino acids connected by peptide chains that exert regulatory roles in intercellular interactions involved in a variety of biological and pathological processes. Emerging evidence suggests that a variety of vasoactive peptides play important roles in the occurrence and development of vascular aging and related diseases such as atherosclerosis, hypertension, vascular calcification, abdominal aortic aneurysms, and stroke. This review will summarize the cumulative roles and mechanisms of several important endogenous vasoactive peptides in vascular aging and vascular aging-related diseases. In addition, we also aim to explore the promising diagnostic function as biomarkers and the potential therapeutic application of endogenous vasoactive peptides in vascular aging-related diseases."

基金机构：National Natural Science Foundation of China; Research Foundation of Soochow University; Priority Academic Program Development of Jiangsu Higher Education Institutions; [81600210]; [82270503]; [31872790]; [32071113]

基金资助正文："AcknowledgmentsThis work was supported by the National Natural Science Foundation of China (Nos. 81600210 and 82270503 to WW Lu and Nos. 31872790 and 32071113 to YF Qi), the Research Foundation of Soochow University (No. NH13400121), and the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions."