Mechanism of Emodin in the Treatment of Rheumatoid Arthritis

作者全名："Cheng, Lianying; Chen, Jie; Rong, Xiaofeng"

作者地址："[Cheng, Lianying; Rong, Xiaofeng] Chongqing Med Univ, Affiliated Hosp 1, Dept Combinat Chinese & Western Med, Chongqing 400016, Peoples R China; [Chen, Jie] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing 400016, Peoples R China"

通信作者："Rong, XF (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Combinat Chinese & Western Med, Chongqing 400016, Peoples R China."

来源：EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000870008500001

JCR分区：Q3

影响因子：2.65

年份：2022

卷号：2022

期号：　

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结束页：　

文献类型：Review

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摘要："Rheumatoid arthritis (RA) is a chronic, systemic, and autoimmune disease, and its main pathological changes are inflammatory cell infiltration accompanied by the secretion and accumulation of a variety of related cytokines, which induce the destruction of cartilage and bone tissue. Therefore, the modulation of inflammatory cells and cytokines is a key therapeutic target for controlling inflammation in RA. This review details the effects of emodin on the differentiation and maturation of T lymphocytes, dendritic cells, and regulatory T cells. In addition, the systematic introduction of emodin directly or indirectly affects proinflammatory cytokines (TNF-alpha, IL-6, IL-1, IL-1 beta, IL-17, IL-19, and M-CSF) and anti-inflammatory cytokines (the secretion of IL-4, IL-10, IL-13, and TGF-beta) through the coregulation of a variety of inflammatory cytokines to inhibit inflammation in RA and promote recovery. Understanding the potential mechanism of emodin in the treatment of RA in detail provides a systematic theoretical basis for the clinical application of emodin in the future."

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