All-trans retinoic acid inhibits the malignant behaviors of hepatocarcinoma cells by regulating ferroptosis

作者全名："Sun, Yanting; He, Yun; Tong, Jishuang; Liu, Daijiang; Zhang, Haodong; He, Tongchuan; Bi, Yang"

作者地址："[Sun, Yanting; Tong, Jishuang; Zhang, Haodong; Bi, Yang] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Stem Cell Biol & Therapy Lab,Chongqing Key Lab Ped, Chongqing 400014, Peoples R China; [He, Yun] Chongqing Med Univ, Childrens Hosp, Dept Pediat Surg, Chongqing 400014, Peoples R China; [Liu, Daijiang] Chongqing Emergency Med Ctr, Dept Gastroenterol, Chongqing 400014, Peoples R China; [He, Tongchuan] Univ Chicago, Dept Surg, Mol Oncol Lab, Med Ctr, Chicago, IL 60637 USA; [Bi, Yang] Chongqing Med Univ, Childrens Hosp, Stem Cell Biol & Therapy Lab, Bldg 7,Room 905,136 Zhongshan Er Rd, Chongqing 400014, Peoples R China"

通信作者："Bi, Y (通讯作者)，Chongqing Med Univ, Childrens Hosp, Stem Cell Biol & Therapy Lab, Bldg 7,Room 905,136 Zhongshan Er Rd, Chongqing 400014, Peoples R China."

来源：GENES & DISEASES

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000870272400008

JCR分区：Q1

影响因子：6.8

年份：2022

卷号：9

期号：6

开始页：1742

结束页：1756

文献类型：Article

关键词：All-trans retinoic acid; Ferroptosis; Hepatocarcinoma; Invasion; Migration

摘要："All-trans retinoic acid (ATRA) can reverse the malignant behaviors of hepatocellular carcinoma (HCC) cells, thereby exerting anti-HCC effect; however, the underlying mechanism is yet to be understood. This study aimed to demonstrate that ATRA is vital to ferroptosis in HCC. Ferroptosis-related genes exhibit different expression in patients with HCC compared to that in healthy individuals. A total of 20 amino acid products were detected in HepG2 cells, the expression level of 5 was decreased after ATRA treatment. ATRA improved the levels of lipid ROS, MDA, and NAPD thorn /NADPH, and reduced the mt-DNA copy number and changed the structure of mitochondria, in HepG2 and Hep3B cells. We found the expression of genes posi-tively correlated with ferroptosis to increase and those negatively correlated to decrease with"

基金机构：Chongqing Science and Technology Commission; Chongqing Municipal Education Commission; [cstc2021jcyj-msxmX0225]; [KJQN201900442]

基金资助正文：This work was supported by a research grant from the Chongqing Science and Technology Commission (No. cstc2021jcyj-msxmX0225 to YB) and a research program of Chongqing Municipal Education Commission (No. KJQN201900442 to YB) .