Super enhancers: Pathogenic roles and potential therapeutic targets for acute myeloid leukemia (AML)

作者全名："Cao, Ziyang; Shu, Yi; Wang, Jinxia; Wang, Chunxia; Feng, Tienan; Yang, Li; Shao, Jingbo; Zou, Lin"

作者地址："[Cao, Ziyang; Wang, Jinxia; Wang, Chunxia; Feng, Tienan; Zou, Lin] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Clin Res Unit, Shanghai 200062, Peoples R China; [Cao, Ziyang; Wang, Jinxia; Wang, Chunxia; Zou, Lin] Shanghai Jiao Tong Univ, Inst Pediat Infect, Sch Med, Immun,Crit Care Med, Shanghai 200062, Peoples R China; [Shu, Yi; Zou, Lin] Chongqing Med Univ, Childrens Hosp, Ctr Clin Mol Lab Med, Chongqing 400014, Peoples R China; [Feng, Tienan] Shanghai Jiao Tong Univ, Clin Res Inst, Sch Med, Shanghai 200025, Peoples R China; [Yang, Li] Chongqing Med Univ, Dept Hematol, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Shao, Jingbo] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Dept Hematol Oncol, Shanghai 200062, Peoples R China"

通信作者："Zou, L (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Clin Res Unit, Shanghai 200062, Peoples R China.; Shao, JB (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Dept Hematol Oncol, Shanghai 200062, Peoples R China."

来源：GENES & DISEASES

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000870272900015

JCR分区：Q1

影响因子：6.8

年份：2022

卷号：9

期号：6

开始页：1466

结束页：1477

文献类型：Review

关键词：AML; Classification; Leukemogenesis; Super enhancer; Therapy targets

摘要："Acute myeloid leukemia (AML) is a malignant hematological tumor with disordered oncogenes/tumor suppressor genes and limited treatments. The potent anti-cancer effects of bromodomain and extra-terminal domain (BET) inhibitors, targeting the key component of super enhancers, in early clinical trials on AML patients, implies the critical role of super enhancers in AML. Here, we review the concept and characteristic of super enhancer, and then summarize the current researches about super enhancers in AML pathogenesis, diagnosis and classification, followed by illustrate the potential super enhancer-related targets and drugs, and propose the future directions of super enhancers in AML. This information provides integrated insight into the roles of super enhancers in this disease. Copyright (c) 2022, Chongqing Medical University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/ by-nc-nd/4.0/)."

基金机构：Natural Science Foundation of China; [82070167]; [81870126]; [81802803]

基金资助正文："This work was partially supported by the Natural Science Foundation of China (No. 82070167, 81870126, and 81802803) ."