"Melanoma: Molecular genetics, metastasis, targeted therapies, immunotherapies, and therapeutic resistance"

作者全名："Wagstaff, William; Mwamba, Rimel N.; Grullon, Karina; Armstrong, Mikhayla; Zhao, Piao; Hendren-Santiago, Bryce; Qin, Kevin H.; Li, Alexander J.; Hu, Daniel A.; Youssef, Andrew; Reid, Russell R.; Luu, Hue H.; Shen, Le; He, Tong-Chuan; Haydon, Rex C."

作者地址："[Wagstaff, William; Mwamba, Rimel N.; Grullon, Karina; Armstrong, Mikhayla] Univ Chicago, Pritzker Sch Med, Med Scientist Training Program, Med Ctr, Chicago, IL 60637 USA; [Wagstaff, William; Zhao, Piao; Hendren-Santiago, Bryce; Qin, Kevin H.; Li, Alexander J.; Hu, Daniel A.; Youssef, Andrew; Reid, Russell R.; Luu, Hue H.; Shen, Le; He, Tong-Chuan; Haydon, Rex C.] Univ Chicago, Dept Orthopaed Surg & Rehabil Med, Mol Oncol Lab, Med Ctr, Chicago, IL 60637 USA; [Zhao, Piao] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthopaed Surg, Chongqing 400016, Peoples R China; [Reid, Russell R.] Univ Chicago, Dept Surg Sect Plast Surg, Lab Craniofacial Suture Biol & Dev, Med Ctr, Chicago, IL 60637 USA; [Shen, Le; He, Tong-Chuan] Univ Chicago, Dept Surg, Med Ctr, Chicago, IL 60637 USA; [He, Tong-Chuan; Haydon, Rex C.] Univ Chicago, Dept Orthopaed Surg & Rehabil Med, Mol Oncol Lab, Med Ctr, 5841 South Maryland Ave,MC3079, Chicago, IL 60637 USA"

通信作者："He, TC; Haydon, RC (通讯作者)，Univ Chicago, Dept Orthopaed Surg & Rehabil Med, Mol Oncol Lab, Med Ctr, 5841 South Maryland Ave,MC3079, Chicago, IL 60637 USA."

来源：GENES & DISEASES

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000870272900024

JCR分区：Q1

影响因子：6.8

年份：2022

卷号：9

期号：6

开始页：1608

结束页：1623

文献类型：Review

关键词：BRAF inhibitors; Checkpoint inhibitors; Drug resistance; Immunotherapy; Melanoma; Melanoma metastasis

摘要："Cutaneous melanoma is a common cancer and cases have steadily increased since the mid 70s. For some patients, early diagnosis and surgical removal of melanomas is life-saving, while other patients typically turn to molecular targeted therapies and immunother-apies as treatment options. Easy sampling of melanomas allows the scientific community to identify the most prevalent mutations that initiate melanoma such as the BRAF, NRAS, and TERT genes, some of which can be therapeutically targeted. Though initially effective, many tumors acquire resistance to the targeted therapies demonstrating the need to investigate compensatory pathways. Immunotherapies represent an alternative to molecular targeted therapies. However, inter-tumoral immune cell populations dictate initial therapeutic"

基金机构："National Institutes of Health [CA226303, DE030480]; Medical Scientist Training Program of the National Institutes of Health [T32 GM007281]; University of Chicago Cancer Center Support Grant [P30CA014599]; National Center for Advancing Translational Sciences of the National Institutes of Health [UL1 TR000430]; Mabel Green Myers Research Endowment Fund; University of Chicago Orthopaedics Alumni Fund"

基金资助正文："The reported work was supported in part by research grant from the National Institutes of Health (CA226303 to TCH, and DE030480 to RRR). WW was supported by the Medical Scientist Training Program of the National Institutes of Health (T32 GM007281). This project was also supported in part by The University of Chicago Cancer Center Support Grant (P30CA014599) and the National Center for Advancing Translational Sciences of the National Institutes of Health through Grant Number UL1 TR000430. TCH was also supported by the Mabel Green Myers Research Endowment Fund and The University of Chicago Orthopaedics Alumni Fund. Funding sources were not involved in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication."