Clinical and electroencephalography characteristics of 41 children with epileptic spasms onset after 1 year of age
作者全名："Yan, Lisi; Deng, Yu; Chen, Jin; Hu, Yue; Hong, Siqi; Jiang, Li"
作者地址："[Yan, Lisi; Deng, Yu; Chen, Jin; Hu, Yue; Hong, Siqi; Jiang, Li] Chongqing Med Univ, Childrens Hosp, Dept Neurol, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China; [Yan, Lisi; Deng, Yu; Chen, Jin; Hu, Yue; Hong, Siqi; Jiang, Li] Minist Educ, Key Lab Child Dev & Disorders, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China; [Yan, Lisi; Deng, Yu; Chen, Jin; Hu, Yue; Hong, Siqi; Jiang, Li] Natl Clin Res Ctr Child Hlth & Disorders Chongqing, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China; [Yan, Lisi; Deng, Yu; Chen, Jin; Hu, Yue; Hong, Siqi; Jiang, Li] China Int Sci & Technol Cooperat Base Child Dev &, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China; [Yan, Lisi; Deng, Yu; Chen, Jin; Hu, Yue; Hong, Siqi; Jiang, Li] Chongqing Key Lab Pediat, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China; [Chen, Jin] Chongqing Med Univ, Childrens Hosp, Dept Neurol, Minist Educ,Key Lab Child Dev & Disorders, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China"
通信作者："Chen, J (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Neurol, Minist Educ,Key Lab Child Dev & Disorders, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China."
来源：EPILEPSY & BEHAVIOR
ESI学科分类：NEUROSCIENCE & BEHAVIOR
WOS号：WOS:000870566100014
JCR分区：Q2
影响因子：2.6
年份：2022
卷号：135
期号：
开始页：
结束页：
文献类型：Article
关键词：Epileptic spasms after 1 year of age; Epileptic encephalopathy; Etiology; Children
摘要："The incidence of epileptic spasms (ES) that begin after the first year of life is much lower than that before 1 year of age. The aim of this study was to identify clinical and electroencephalography (EEG) character-istics, etiologies, treatments, and prognoses in pediatric patients with ES onset after 1 year of age. Forty-one children were retrospectively identified in Children's Hospital of Chongqing Medical University between January 1, 2020 and December 1, 2021. ES onset after 1 year of age have diverse presentations. Although most occur in clusters, are symmetrical and flexional, and occur frequently during awakening, some are characterized as isolated and asymmetrical, have a tonic component, and can also occur during sleep. The hypsarrhythmia variants and focal or multifocal discharges occur alternately in the interictal period, and the focal spikes and slow waves predominated in the unilateral temporal or frontotemporal areas. These patients had diverse etiologies, including structural (51.2 % of patients) and genetic (22.0 %) ones, and 11 patients (26.8 %) had an unknown etiology. No patients in our study had an infectious or immune-mediated etiology. Forty-eight percent of patients responded to hydrocortisone and/or adreno-corticotropic hormone. The efficacy of antiepileptic drug therapy was lower in patients who did not receive concurrent steroid therapy. However, ES onset after 1 year of age caused by a tumor, brain mal-formation, or other focal lesions, may be cured by focal cortical resection despite a lack of clearly localized EEG surface anomalies. Delays in motor, language, and cognitive development, or behavioral problems were observed in all but three patients.(c) 2022 Elsevier Inc. All rights reserved."
基金机构：National Natural Science Foundation of China (NSFC); [81501056]
基金资助正文：This work was supported by the National Natural Science Foundation of China (NSFC Grant 81501056) .
