Long-term effects of hematopoietic growth factors in aplastic anemia patients treated with immunosuppression: Meta-analysis of randomized controlled trials

作者全名："Wang, Anzi; Su, Dongyun; Luo, Jingyuan; Fu, Yuhan; Li, Qing; Chen, Shu"

作者地址："[Wang, Anzi; Luo, Jingyuan; Fu, Yuhan; Li, Qing; Chen, Shu] Chongqing Med Univ, Dept Hematol, Affiliated Hosp 2, Chongqing 40010, Peoples R China; [Su, Dongyun] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Chen, S (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Hematol, 74 Linjiang Rd, Chongqing 40010, Peoples R China."

来源：MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000871577800097

JCR分区：Q2

影响因子：1.6

年份：2022

卷号：101

期号：42

开始页：　

结束页：　

文献类型：Review

关键词：aplastic anemia; hematopoietic growth factors; immunosuppressive therapy; meta-analysis

摘要："Background and purpose: Immunosuppressive therapy is the frontline treatment for aplastic anemia patients ineligible for transplantation. The long-term effects of hematopoietic growth factors (HGF) added to standard immunosuppressive therapy are still unclear. We performed a systematic review and meta-analysis to clarify this issue. Methods: A comprehensive search of databases was conducted including 5 international electronic databases (Cochrane, PubMed, Embase, Web of Science, and LILACS) and 4 Chinese electronic databases (Chinese Bio-medicine Database, Chinese National Knowledge Infrastructure, WanFang Data, and China Science and Technology Journal Database databases) from database inception until February, 2022. We included randomized controlled trials that assigned patients with acquired aplastic anemia treated with immunosuppressive therapy (IST), which compared between the addition of HGF and placebo or no treatment. The co-primary outcome were the overall survival (OS) and late clonal malignant evolution at the end of follow-up. Results: Nine randomized controlled trials including 719 participants were identified. The addition of growth factors to immunosuppression yielded no difference in OS (relative risks [RR], 1.08, 95% confidence interval [CI] 0.99-1.18). HGF was not associated with higher occurrence of secondary myelodysplastic syndromes/acute myeloid leukemia (RR, 1.09, 95% CI 0.43-2.78) or paroxysmal nocturnal hemoglobulinemia (RR, 1.38, 95% CI 0.68-2.81) at the end of follow-up. No difference were found in overall response (RR, 1.16, 95% CI 0.98-1.37), infections occurrence (RR, 0.82; 95% CI, 0.51-1.31) or relapse (RR, 0.65; 95% CI, 0.37-1.13). Conclusions: HGF as an adjunct to IST has no impact on long-term OS, late clonal malignant evolution, response rate, relapse or infections occurrence. HGF could be added to standard IST for high-risk patients with delayed neutrophil recovery without concern for long-term consequences but could not be recommended as routine clinical practice."

基金机构：　

基金资助正文：