Application of Microfluidics in Drug Development from Traditional Medicine

作者全名："Li, Xue; Fan, Xiaoming; Li, Zhu; Shi, Lina; Liu, Jinkuan; Luo, Hongzhi; Wang, Lijun; Du, Xiaoxin; Chen, Wenzhu; Guo, Jiuchuan; Li, Chenzhong; Liu, Shan"

作者地址："[Li, Xue] Sichuan Hanyuan Cty Peoples Hosp, Hanyuan 625300, Peoples R China; [Fan, Xiaoming] Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Dept Lab Med, Chengdu 610072, Peoples R China; [Fan, Xiaoming; Liu, Shan] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Chengdu 610072, Peoples R China; [Li, Zhu] Chengdu Univ Tradit Chinese Med, Coll Med Technol, Chengdu 610075, Peoples R China; [Shi, Lina; Liu, Jinkuan] Univ Elect Sci & Technol China, Sch Med, Chengdu 610054, Peoples R China; [Luo, Hongzhi] Zunyi Med Univ, Dept Lab Med, Affiliated Hosp 3, Peoples Hosp Zunyi 1, Zunyi 563002, Guizhou, Peoples R China; [Wang, Lijun] Southwest Jiaotong Univ, Dept Ophthalmol, Peoples Hosp Chengdu 3, Affiliated Hosp, Chengdu 610031, Peoples R China; [Du, Xiaoxin] Univ Elect Sci & Technol, Off Sci Res & Dev, Chengdu 610054, Peoples R China; [Chen, Wenzhu] First Peoples Hosp Longquanyi Dist, Dept Blood Transfus, Chengdu 610041, Peoples R China; [Guo, Jiuchuan] Chongqing Med Univ, Coll Lab Med, MOE Key Lab Lab Med Diagnost, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Li, Chenzhong] Tulane Univ, Sch Med, Dept Biochem & Mol Biol, New Orleans, LA 70112 USA; [Liu, Shan] Univ Elect Sci & Technol China, Dept Med Genet, Sichuan Prov Key Lab Human Dis Gene Study, Sichuan Acad Med Sci, Chengdu 610072, Peoples R China"

通信作者："Liu, S (通讯作者)，Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Chengdu 610072, Peoples R China.; Guo, JC (通讯作者)，Chongqing Med Univ, Coll Lab Med, MOE Key Lab Lab Med Diagnost, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China.; Li, CZ (通讯作者)，Tulane Univ, Sch Med, Dept Biochem & Mol Biol, New Orleans, LA 70112 USA.; Liu, S (通讯作者)，Univ Elect Sci & Technol China, Dept Med Genet, Sichuan Prov Key Lab Human Dis Gene Study, Sichuan Acad Med Sci, Chengdu 610072, Peoples R China."

来源：BIOSENSORS-BASEL

ESI学科分类：　

WOS号：WOS:000872180400001

JCR分区：Q2

影响因子：5.4

年份：2022

卷号：12

期号：10

开始页：　

结束页：　

文献类型：Review

关键词：microfluidics; drug development; traditional medicine; bioMEMS

摘要："While there are many clinical drugs for prophylaxis and treatment, the search for those with low or no risk of side effects for the control of infectious and non-infectious diseases is a dilemma that cannot be solved by today's traditional drug development strategies. The need for new drug development strategies is becoming increasingly important, and the development of new drugs from traditional medicines is the most promising strategy. Many valuable clinical drugs have been developed based on traditional medicine, including drugs with single active ingredients similar to modern drugs and those developed from improved formulations of traditional drugs. However, the problems of traditional isolation and purification and drug screening methods should be addressed for successful drug development from traditional medicine. Advances in microfluidics have not only contributed significantly to classical drug development but have also solved many of the thorny problems of new strategies for developing new drugs from traditional drugs. In this review, we provide an overview of advanced microfluidics and its applications in drug development (drug compound synthesis, drug screening, drug delivery, and drug carrier fabrication) with a focus on its applications in conventional medicine, including the separation and purification of target components in complex samples and screening of active ingredients of conventional drugs. We hope that our review gives better insight into the potential of traditional medicine and the critical role of microfluidics in the drug development process. In addition, the emergence of new ideas and applications will bring about further advances in the field of drug development."

基金机构：Natural Science Foundation of Sichuan Provincial Department of Science and Technology [2022NSFSC1446]; Science and Technology Project of Health Commission of Sichuan Province [19ZD013]; Central Universities Foundation of University of Electronic Science and Technology of China [ZYGX2019J109]; National Natural Science Foundation of China [81603018]

基金资助正文："This study was supported by the Natural Science Foundation of Sichuan Provincial Department of Science and Technology (2022NSFSC1446), Science and Technology Project of Health Commission of Sichuan Province (No. 19ZD013), the Central Universities Foundation of University of Electronic Science and Technology of China (No. ZYGX2019J109), and National Natural Science Foundation of China (No. 81603018)."