"Pyroptosis in periodontitis: From the intricate interaction with apoptosis, NETosis, and necroptosis to the therapeutic prospects"

作者全名："Xu, Xiaohui; Zhang, Tingwei; Xia, Xuyun; Yin, Yuanyuan; Yang, Sihan; Ai, Dongqing; Qin, Han; Zhou, Mengjiao; Song, Jinlin"

作者地址："[Xu, Xiaohui; Zhang, Tingwei; Yin, Yuanyuan; Yang, Sihan; Ai, Dongqing; Qin, Han; Zhou, Mengjiao; Song, Jinlin] Chongqing Med Univ, Coll Stomatol, Chongqing, Peoples R China; [Xu, Xiaohui; Zhang, Tingwei; Yin, Yuanyuan; Yang, Sihan; Ai, Dongqing; Qin, Han; Zhou, Mengjiao; Song, Jinlin] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China; [Xu, Xiaohui; Zhang, Tingwei; Yin, Yuanyuan; Yang, Sihan; Ai, Dongqing; Qin, Han; Zhou, Mengjiao; Song, Jinlin] Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China; [Xia, Xuyun] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing, Peoples R China"

通信作者："Song, JL (通讯作者)，Chongqing Med Univ, Coll Stomatol, Chongqing, Peoples R China.; Song, JL (通讯作者)，Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China.; Song, JL (通讯作者)，Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China."

来源：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:000872787700001

JCR分区：Q2

影响因子：5.7

年份：2022

卷号：12

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：pyroptosis; periodontitis; programmed cell death; diabetes; cardiovascular diseases; rheumatoid arthritis

摘要："Periodontitis is highly prevalent worldwide. It is characterized by periodontal attachment and alveolar bone destruction, which not only leads to tooth loss but also results in the exacerbation of systematic diseases. As such, periodontitis has a significant negative impact on the daily lives of patients. Detailed exploration of the molecular mechanisms underlying the physiopathology of periodontitis may contribute to the development of new therapeutic strategies for periodontitis and the associated systematic diseases. Pyroptosis, as one of the inflammatory programmed cell death pathways, is implicated in the pathogenesis of periodontitis. Progress in the field of pyroptosis has greatly enhanced our understanding of its role in inflammatory diseases. This review first summarizes the mechanisms underlying the activation of pyroptosis in periodontitis and the pathological role of pyroptosis in the progression of periodontitis. Then, the crosstalk between pyroptosis with apoptosis, necroptosis, and NETosis in periodontitis is discussed. Moreover, pyroptosis, as a novel link that connects periodontitis with systemic disease, is also reviewed. Finally, the current challenges associated with pyroptosis as a potential therapeutic target for periodontitis are highlighted."

基金机构："National Natural Science Foundation of China [82101014, 81771082, 31971282]; China postdoctoral Science Foundation [2021M700628]; Natural Science Foundation of Chongqing [cstc2021jcyj-bsh0005]; Chongqing Graduate Tutor Team [dstd201903]"

基金资助正文："This work was financially supported by funding from the National Natural Science Foundation of China (Grant No. 82101014; 81771082; 31971282), China postdoctoral Science Foundation (Grant No. 2021M700628), Natural Science Foundation of Chongqing (Grant No. cstc2021jcyj-bsh0005), and the Chongqing Graduate Tutor Team (2019) (Grant No. dstd201903)."