Alteration in NMDAR subunits in different brain regions of chronic unpredictable mild stress (CUMS) rat model

作者全名："Chen, Jing; Luo, Yanmin; Liang, Xin; Kong, Xiangru; Xiao, Qian; Tang, Jing; Qi, Yingqiang; Tang, Yong; Xiu, Yun"

作者地址："[Tang, Jing; Tang, Yong] Chongqing Med Univ, Dept Histol & Embryol, Chongqing 400016, Peoples R China; [Chen, Jing; Qi, Yingqiang; Xiu, Yun] Chongqing Med Univ, Inst Life Sci, Mol Med Diagnost & Testing Ctr, Chongqing 400016, Peoples R China; [Luo, Yanmin] Chongqing Med Univ, Dept Physiol, Chongqing 400016, Peoples R China; [Liang, Xin] Chongqing Med Univ, Dept Pathophysiol, Chongqing 400016, Peoples R China; [Kong, Xiangru] Chongqing Med Univ, Dept Pediat Surg Oncol, Childrens Hosp, Chongqing 400014, Peoples R China; [Xiao, Qian] Chongqing Med Univ, Dept Radioact Med, Chongqing 400016, Peoples R China"

通信作者："Tang, Y (通讯作者)，Chongqing Med Univ, Dept Histol & Embryol, Chongqing 400016, Peoples R China.; Xiu, Y (通讯作者)，Chongqing Med Univ, Inst Life Sci, Mol Med Diagnost & Testing Ctr, Chongqing 400016, Peoples R China."

来源：TRANSLATIONAL NEUROSCIENCE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000874124800001

JCR分区：Q4

影响因子：2.1

年份：2022

卷号：13

期号：1

开始页：379

结束页：389

文献类型：Article

关键词：depression; GluN2B; GluN3A; medial prefrontal cortex; corpus callosum

摘要："N-Methyl-d-aspartate receptor (NMDAR) signaling pathway has been implicated in the pathogenesis and treatment of depression. However, the role of NMDAR subunits in depression is still unclear. In this study, alteration in all seven NMDAR subunits in several brain areas of rats exposed to chronic unpredictable mild stress (CUMS), an animal model of depression, was detected. Our findings demonstrated that: (1) CUMS could induce a reduction in sucrose preference, an indicator of typical depression-like behaviors; (2) CUMS significantly reduced the NMDAR subunits of GluN2B and GluN3 in the medial prefrontal cortex (mPFC), but not altered all seven NMDAR subunits in hippocampus and corpus callosum of rats; (3) subunit composition of NMDARs in corpus callosum was different from that in mPFC, PFC and hippocampus; and (4) the mRNA expressions of GluN2B, GluN3A and GluN3B in mPFC as well as mRNA expression of GluN2C in corpus callosum were correlated to sucrose preference in rats. These findings suggested that GluN2B and GluN3 in mPFC may contribute to the pathophysiology of depression."

基金机构："National Natural Science Foundation of China [81871073, 81301149]; ""SKY project"" - institute of Life Institute, Chongqing Medical University [202004, 202006]"

基金资助正文："This work was supported by grants from National Natural Science Foundation of China (No. 81871073 and 81301149) and the ""SKY project"" granted by institute of Life Institute (202004 and 202006), Chongqing Medical University."