Vitamin D categories and postpartum thyroid function in women with hypothyroidism

作者全名："Chen, Yanrong; Zhang, Sijing; Hu, Lingling; Dong, Lun; Liu, Qiuhong; Liu, Yunting; Cheng, Wei; Liu, Dongfang; Yang, Gangyi; Li, Ke"

作者地址："[Chen, Yanrong; Zhang, Sijing; Hu, Lingling; Dong, Lun; Liu, Qiuhong; Liu, Yunting; Cheng, Wei; Liu, Dongfang; Yang, Gangyi; Li, Ke] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing, Peoples R China"

通信作者："Li, K (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing, Peoples R China."

来源：FRONTIERS IN NUTRITION

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000874594800001

JCR分区：Q2

影响因子：5

年份：2022

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：vitamin D nutrition; postpartum; hypothyroidism; thyroid function; thyroid autoantibody

摘要："ObjectiveTo analyze the related factors of the postpartum thyroid function in women with overt hypothyroidism (OH)/subclinical hypothyroidism (SCH) and explore the effects of vitamin D categories. MethodsThyroid hormones, thyroid autoantibody, and serum 25OHD levels were continuously recorded from the first trimester of pregnancy (T1) to the 12th postpartum month. Logistic regression analysis and Cox regression analysis were used to screen the related factors of postpartum thyroid function, and the Latent Class Growth Model was performed to analyze the trajectory characteristics of serum 25OHD levels. ResultsTotally, 252 pregnant women with OH/SCH were enrolled in the study. In the 12th month postpartum, 36.5% of the patients improved thyroid function, 37.3% continued hypothyroidism, and 26.2% developed thyroid dysfunction. Vitamin D sufficiency, positive TPOAb, and positive TgAb in T1 were independent prognostic factors of postpartum thyroid function. Vitamin D sufficiency in T1 was illustrated as an independent factor of the improved postpartum thyroid function, but the protective effect for the developed postpartum thyroid dysfunction was only confirmed in TPOAb-positive patients. Cox regression analysis further confirmed the effects of vitamin D categories. Notably, the high-level 25OHD trajectory during pregnancy and postpartum could predict improved postpartum thyroid function and decrease the risk of developed postpartum thyroid dysfunction. ConclusionAppropriate vitamin D nutrition during pregnancy and postpartum may be beneficial to postpartum thyroid function."

基金机构："National Natural Science Foundation of China; Natural Science Foundation of Chongqing; Science and Health Joint Medical Research Project of Chongqing; Senior Medical Talents Program of Chongqing for Young and Middle-aged, and the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University; [81671381]; [cstc2021jcyj-msxmX0169]; [2022GDRC018]"

基金资助正文："Funding We received funding from the National Natural Science Foundation of China (81671381), the Natural Science Foundation of Chongqing (cstc2021jcyj-msxmX0169), the Science and Health Joint Medical Research Project of Chongqing (2022GDRC018), Senior Medical Talents Program of Chongqing for Young and Middle-aged, and the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University."