The value of plasma insulin-like growth factor 1 and interleukin-18 in the diagnosis of bronchopulmonary dysplasia in premature infants

作者全名："Huang, Lie; Guo, Ning; Cheng, Meile; Wang, Jianhui; Chen, Feifan; Shi, Yuan"

作者地址："[Huang, Lie; Wang, Jianhui; Chen, Feifan; Shi, Yuan] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Neonatol, Minist Educ,Key Lab Child Dev & Disorders,Childr, Chongqing, Peoples R China; [Guo, Ning; Cheng, Meile] Ningxia Med Univ, Peoples Hosp Yinchuan 1, Dept Neonatol, Yinchuan, Peoples R China"

通信作者："Shi, Y (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Neonatol, Minist Educ,Key Lab Child Dev & Disorders,Childr, Chongqing, Peoples R China."

来源：FRONTIERS IN PEDIATRICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000875727400001

JCR分区：Q1

影响因子：2.6

年份：2022

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：bronchopulmonary dysplasia; very low birth weight (VLBW); IGF-1 (insulin-like growth factor 1); IL-18; inflammation

摘要："ObjectiveTo explore the diagnostic value of IGF-1 and IL-18 in premature infants with BPD. MethodsThrough a prospective observational study, the serum samples of infants in the BPD group and the non-BPD group were collected at different targeted time points, and the serum IGF-1 and IL-18 concentrations were dynamically monitored by ELISA. The Student t-test and one-way analysis of variance were adopted to analyze data, and the receiver operating characteristic (ROC) curve was used to test the diagnostic value. ResultA total of 90 VLBW premature infants admitted to NICU between January 2020 and 2021 were finally included. Compared with the non-BPD group, infants diagnosed with BPD had a significantly lower serum concentration of IGF-1 (P < 0.05) but a higher level of IL-18 (P < 0.05) on days 1, 7, 14, and 28 after birth. With the ROC curve analysis, the serum concentration IGF-1 on day 14 and IL-18 on day 28 reported high sensitivity and specificity to predict the risk of BPD (IGF-1: sensitivity: 89.29%, specificity: 77.78%, AUC: 0.8710; IL-18: sensitivity: 53.57%, specificity: 83.33%, AUC: 0.7887). And more substantial predictive power was found in combined analysis of IGF-1 and serum IL-18 on day 14: the sensitivity was 91.07% and the specificity was 83.33%, with the AUC of 0.9142. ConclusionIGF-1 and IL-18 might be closely involved in the occurrence and development of BPD. The serum concentration of IGF-1 combined with IL-18 could be potentially sensitive markers for the early diagnosis and severity of BPD."

基金机构：General Program of the Healthy Yinchuan; General project of Yinchuan Municipal Science and Technology Bureau; [JKYC-KJ2021-023]; [2020-SF-005]

基金资助正文："Funding This work was supported by the General Program of the Healthy Yinchuan (JKYC-KJ2021-023), General project of Yinchuan Municipal Science and Technology Bureau (2020-SF-005)"