Early life exposure to triclosan from antimicrobial daily necessities may increase the potential risk of autism spectrum disorder: A multicenter study in China

作者全名："Wu, Qionghui; Yang, Ting; Chen, Li; Dai, Ying; Wei, Hua; Jia, Feiyong; Hao, Yan; Li, Ling; Zhang, Jie; Wu, Lijie; Ke, Xiaoyan; Yi, Mingji; Hong, Qi; Chen, Jinjin; Fang, Shuanfeng; Wang, Yichao; Wang, Qi; Jin, Chunhua; Hu, Ronggui; Chen, Jie; Li, Tingyu"

作者地址："[Wu, Qionghui; Yang, Ting; Chen, Li; Dai, Ying; Wei, Hua; Chen, Jie; Li, Tingyu] Chongqing Med Univ, Chongqing Key Lab Childhood Nutr & Hlth, Minist Educ,Key Lab Child Dev & Disorders, Childrens Hosp,Natl Clin Res Ctr Child Hlth & Dis, Chongqing, Peoples R China; [Jia, Feiyong] First Hosp Jilin Univ, Dept Dev & Behav Pediat, Changchun, Peoples R China; [Hao, Yan] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pediat, Wuhan, Peoples R China; [Li, Ling] Hainan Women & Childrens Med Ctr, Dept Children Rehabil, Haikou, Hainan, Peoples R China; [Zhang, Jie] Xian Childrens Hosp, Children Hlth Care Ctr, Xian, Peoples R China; [Wu, Lijie] Harbin Med Univ, Dept Childrens & Adolescent Hlth, Publ Hlth Coll, Harbin, Peoples R China; [Ke, Xiaoyan] Nanjing Brain Hosp, Child Mental Hlth Res Ctr, Nanjing, Peoples R China; [Yi, Mingji] Qingdao Univ, Dept Child Hlth Care, Affiliated Hosp, Qingdao, Peoples R China; [Hong, Qi] Maternal & Child Hlth Hosp Baoan, Shenzhen, Peoples R China; [Chen, Jinjin] Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Dept Child Healthcare, Shanghai, Peoples R China; [Fang, Shuanfeng] Zhengzhou Univ, Childrens Hosp, Zhengzhou, Peoples R China; [Wang, Yichao] Hunan Prov Maternal & Child Hlth Care Hosp, NHC Key Lab Birth Defect Res & Prevent, Changsha, Peoples R China; [Wang, Qi] Deyang Matern & Child Healthcare Hosp, Deyang, Sichuan, Peoples R China; [Jin, Chunhua] Capital Inst Pediat, Dept Children Hlth Care, Beijing, Peoples R China; [Hu, Ronggui] Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai, Peoples R China; [Hu, Ronggui] Chinese Acad Sci, State Key Lab Mol Biol, CAS Ctr Excellence Mol Cell Sci, Inst Biochem & Cell Biol, Shanghai, Peoples R China"

通信作者："Li, TY (通讯作者)，Chongqing Med Univ, Childrens Nutr Res Ctr, Childrens Hosp, Chongqing 400014, Peoples R China."

来源：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

ESI学科分类：ENVIRONMENT/ECOLOGY

WOS号：WOS:000877580300008

JCR分区：Q1

影响因子：6.8

年份：2022

卷号：247

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Autism spectrum disorder; Triclosan; Risk factor; Core symptoms; Multicenter

摘要："Background: Autism spectrum disorders (ASD) are a group of complex neurodevelopmental disorders with un-clear etiologies. Our recent work indicated that maternal exposure to triclosan (TCS) significantly increased the autistic-like behavior in rats, possibly through disrupting neuronal retinoic acid signaling. Although environ-mental endocrine disruptors (EEDs) have been associated with autism in humans, the relationship between TCS, one of the EEDs found in antibacterial daily necessities, and autism has received little attention.Objective: The aims of this multicenter study were to evaluate TCS concentrations in typically developing (TD) children and ASD children, and to determine the relationship between TCS levels and the core symptoms of ASD children.Methods: A total of 1345 children with ASD and 1183 TD children were enrolled from 13 cities in China. Ages ranged between 2 and 7 years. A questionnaire was used to investigate the maternal use of antibacterial daily necessities (UADN) during pregnancy. The core symptoms of ASD were evaluated using the Autism Behavior Checklist (ABC), Childhood Autism Rating Scale (CARS), Social Response Scale (SRS), and the Children Neu-ropsychological and Behavior Scale-Revision 2016 (CNBS-R2016). The TCS concentration was measured using LC-MS/MS.Results: Maternal UADN during pregnancy may be an unrecognized potential environmental risk factor for ASD (OR=1.267, P = 0.023). Maternal UADN during pregnancy strongly correlated with TCS levels in the offspring (Adjusted beta = 0.277, P < 0.001). TCS concentration was higher in ASD children (P = 0.005), and positively correlated with ABC (Sensory subscales: P = 0.03; Social self-help subscales: P = 0.011) and SRS scale scores (Social awareness subscales: P = 0.045; Social communication subscales: P = 0.001; Autism behavior manner-isms subscales: P = 0.006; SRS total score: P = 0.003) in ASD children. This association was more pronounced in boys than in girls.Conclusion: To our knowledge, this is the first case-control study to examine the correlation between TCS and ASD. Our results suggest that maternal UADN during pregnancy may be a potential risk of ASD in offspring. Further detection of TCS levels showed that maternal UADN during pregnancy may be associated with excessive TCS exposure. In addition, the level of TCS in children with ASD is higher than TD children. The higher levels of TCS in children with ASD may be significantly associated with more pronounced core symptoms, and this as-sociation was more significant in male children with ASD."

基金机构："National Natural Science Foundation of China [81771223, 31971089, 81770526]; Guangzhou Key Project in ""Early diagnosis and treatment of autism spectrum disorders"" [202007030002]; Guangdong Key Project in ""Development of new tools for diagnosis and treatment of Autism"" [2018B030335001]; Chongqing Science and Technology Bureau Research Project (Technological Innovation and Application Development in Chongqing) [cstc2019jscx-msxmX0217]; Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission, and Science and Technology Bureau) [2019MSXM037]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (No. 81771223, 31971089, 81770526), the Guangzhou Key Project in ""Early diagnosis and treatment of autism spectrum disorders"" (202007030002), the Guangdong Key Project in ""Development of new tools for diagnosis and treatment of Autism"" (2018B030335001), and the Chongqing Science and Technology Bureau Research Project (Technological Innovation and Application Development in Chongqing) [grant number cstc2019jscx-msxmX0217], the Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission, and Science and Technology Bureau) [grant number 2019MSXM037]."