Transcriptomic profile analysis of the left atrium in spontaneously hypertensive rats in the early stage
作者全名："Fang, Qinghua; Wang, Jing; Wei, Jiangjun; Long, Xianglin; Wang, Yao; He, Jiacheng; Yuan, Xin; Du, Jianlin"
作者地址："[Fang, Qinghua; Wang, Jing; Wei, Jiangjun; Long, Xianglin; Wang, Yao; He, Jiacheng; Du, Jianlin] Chongqing Med Univ, Affiliated Hosp 2, Dept Cardiol, Chongqing, Peoples R China; [Yuan, Xin] Chongqing Med Univ, Affiliated Hosp 2, Dept Nephrol, Chongqing, Peoples R China"
通信作者："Du, JL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Cardiol, Chongqing, Peoples R China."
来源：FRONTIERS IN PHARMACOLOGY
ESI学科分类：PHARMACOLOGY & TOXICOLOGY
WOS号：WOS:000878166700001
JCR分区：Q1
影响因子：5.6
年份：2022
卷号：13
期号：
开始页：
结束页：
文献类型：Article
关键词：hypertension; left atrium; transcriptome; atrial fibrosis; cardiac metabolism changes
摘要："Left atrial remodeling, characterized by enlargement and hypertrophy of the left atrium and increased fibrosis, was accompanied by an increased incidence of atrial fibrillation. While before morphological changes at the early stage of hypertension, how overloaded hypertension influences the transcriptomic profile of the left atrium remains unclear. Therefore, RNA-sequencing was performed to define the RNA expressing profiles of left atrium in spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats as a control group. We also compared the changes in the RNA expression profiles in SHRs treated with an angiotensin receptor blocker (ARB) and angiotensin receptor-neprilysin inhibitor (ARNI) to assess the distinct effects on the left atrium. In total, 1,558 differentially expressed genes were found in the left atrium between WKY rats and SHRs. Bioinformatics analysis showed that these mRNAs could regulate upstream pathways in atrial remodeling through atrial fibrosis, inflammation, electrical remodeling, and cardiac metabolism. The regulated transcripts detected in the left atrial tissue in both the ARB-treated and ARNI-treated groups were related to metabolism. In contrast to the ARB-treated rates, the transcripts in ARNI-treated rats were mapped to the cyclic guanosine monophosphate-protein kinase G signaling pathway."
基金机构："National Natural Science Foundation of China (NSFC) [81900631, 82270281]; China Postdoctoral Science Foundation [2019M653354]; Natural Science Foundation Postdoctoral Program of Chongqing Science and Technology Bureau [cstc2019jcyj-bsh0012]; Natural Science Foundation of Chongqing Science and Technology Commission [cstc2020jcyj-msxmX0210]; Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) [2020FYYX047]; Future Medicine Youth Innovation Team Development Support Program of Chongqing Medical University [W0133]; Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University"
基金资助正文："This work was supported by grants from the National Natural Science Foundation of China (NSFC) (81900631, 82270281), China Postdoctoral Science Foundation Grant (2019M653354), Natural Science Foundation Postdoctoral Program of Chongqing Science and Technology Bureau (cstc2019jcyj-bsh0012), Natural Science Foundation of Chongqing Science and Technology Commission (cstc2020jcyj-msxmX0210), and Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) (2020FYYX047), Future Medicine Youth Innovation Team Development Support Program of Chongqing Medical University (W0133), and Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University."
