Multifunctional hydrogels for wound dressings using xanthan gum and polyacrylamide

作者全名："Tang, Song; Gong, Zhoujie; Wang, Zefan; Gao, Xia; Zhang, Xiaonan"

作者地址："[Tang, Song; Gong, Zhoujie; Zhang, Xiaonan] Chongqing Med Univ, Coll Stomatol, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China; [Wang, Zefan] Chinese Acad Sci, Shenzhen Inst Adv Elect Mat, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China; [Gao, Xia] Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China; [Gao, Xia] Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, 266 Fangzheng Ave, Chongqing 400714, Peoples R China; [Zhang, Xiaonan] Chongqing Med Univ, Coll Stomatol, 426 Songshibei Rd, Chongqing 401147, Peoples R China"

通信作者："Gao, X (通讯作者)，Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, 266 Fangzheng Ave, Chongqing 400714, Peoples R China.; Zhang, XA (通讯作者)，Chongqing Med Univ, Coll Stomatol, 426 Songshibei Rd, Chongqing 401147, Peoples R China."

来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000878627200008

JCR分区：Q1

影响因子：8.2

年份：2022

卷号：217

期号：　

开始页：944

结束页：955

文献类型：Article

关键词：Hydrogel dressings; Xanthan gum; Mechanical properties; Wound healing; Release behavior

摘要："Developing advanced dressings that integrate multiple functions is one of the major challenges in current clinical wound treatment. In this study, Xanthan gum (XG) and polyacrylamide (PAAm) materials were used to prepare hydrogel dressings by one-pot method. With the combination of the PAAm network and the XG network, the PAAm-XG hydrogels showed the tensile strength of 0.36 MPa and the stretchability as large as 2078 %. The prepared PAAm-XG hydrogels had excellent water uptake efficiency with the swelling ratio of 1200 %. Besides, the developed dressings possessed outstanding biocompatibility, universal adhesion and self-healing ability. More importantly, the PAAm-XG hydrogels can be successfully loaded with Cefixime and human recombinant epidermal growth factor, and these loaded hydrogels released these bioactive molecules in sustained ways. As a result, both E. coli and S. aureus bacteria were inactivated after contacting with the Cefixime-loaded hydrogels for 24 h. Furthermore, in vivo data demonstrated that the PAAm-XG hydrogel dressings significantly accelerated the wound healing in a mouse model. All of these indicate that the multifunctional PAAm-XG hydrogels are promising candidates for wound treatment."

基金机构：Young and Middle-aged Senior Medical Talents studio of Chongqing [ZQNYXGDRCGZS2019004]; National Natural Science Foundation of China [81700982]

基金资助正文：Funding This work is financially supported by Young and Middle-aged Senior Medical Talents studio of Chongqing (No: ZQNYXGDRCGZS2019004) and the National Natural Science Foundation of China (81700982) .