Photoacoustic mediated multifunctional tumor antigen trapping nanoparticles inhibit the recurrence and metastasis of ovarian cancer by enhancing tumor immunogenicity

作者全名："Zhong, Xiaowen; Li, Chenyang; Zhao, Guangzong; Li, Mengmeng; Chen, Shuning; Cao, Yang; Wang, Qi; Sun, Jiangchuan; Zhu, Shenyin; Chang, Shufang"

作者地址："[Zhong, Xiaowen; Li, Chenyang; Zhao, Guangzong; Li, Mengmeng; Chen, Shuning; Sun, Jiangchuan; Chang, Shufang] Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Cao, Yang] Chongqing Med Univ, Chongqing Key Lab Ultrasound Mol Imaging, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Wang, Qi] Chongqing Med Univ, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China; [Zhu, Shenyin] Chongqing Med Univ, Dept Pharm, Affiliated Hosp 1, Chongqing 400042, Peoples R China"

通信作者："Chang, SF (通讯作者)，Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 2, Chongqing 400010, Peoples R China.; Zhu, SY (通讯作者)，Chongqing Med Univ, Dept Pharm, Affiliated Hosp 1, Chongqing 400042, Peoples R China."

来源：JOURNAL OF NANOBIOTECHNOLOGY

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000878740400002

JCR分区：Q1

影响因子：10.2

年份：2022

卷号：20

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Antigen capture; Immunogenic cell death; Tumor immunotherapy; Photodynamic therapy; Photothermal therapy; Photoacoustic imaging

摘要："The hypoimmunogenicity of tumors is one of the main bottlenecks of cancer immunotherapy. Enhancing tumor immunogenicity can improve the efficacy of tumor immunotherapy by increasing antigen exposure and presentation, and establishing an inflammatory microenvironment. Here, a multifunctional antigen trapping nanoparticle with indocyanine green (ICG), aluminum hydroxide (Al(OH)(3)) and oxaliplatin (OXA) (PPIAO) has been developed for tumor photoacoustic/ultrasound dual-modality imaging and therapy. The combination of photothermal/photodynamic therapy and chemotherapy induced tumor antigen exposure and release through immunogenic death of tumor cells. A timely capture and storage of antigens by aluminum hydroxide enabled dendritic cells to recognize and present those antigens spatiotemporally. In an ovarian tumor model, the photoacoustic-mediated PPIAO NPs combination therapy achieved a transition from ""cold tumor"" to ""hot tumor"" that promoted more CD8(+) T lymphocytes activation in vivo and intratumoral infiltration, and successfully inhibited the growth of primary and metastatic tumors. An in situ tumor vaccine effect was produced from the treated tumor tissue, assisting mice against the recurrence of tumor cells. This study provided a simple and effective personalized tumor vaccine strategy for better treatment of metastatic and recurrent tumors. The developed multifunctional tumor antigen trapping nanoparticles may be a promising nanoplatform for integrating multimodal imaging monitoring, tumor treatment, and tumor vaccine immunotherapy."

基金机构：Natural Science Foundation of China [81972439]; postgraduate research and innovation projects of Chong Municipal Education Commission [CYB21180]; Chongqing Medical Scientific Research Project [2022ZDXM007]; Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University

基金资助正文："This work was supported by the Natural Science Foundation of China [81972439], and the postgraduate research and innovation projects of Chong Municipal Education Commission (CYB21180), Chongqing Medical Scientific Research Project (2022ZDXM007) and Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University."