PASylation improves pharmacokinetic of liposomes and attenuates anti-PEG IgM production: An alternative to PEGylation

作者全名："Zhang, Qianyu; Li, Sai; Wu, Wen; Xia, Xuefeng; Zhang, Jinqiang"

作者地址："[Zhang, Qianyu] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China; [Li, Sai; Wu, Wen; Xia, Xuefeng; Zhang, Jinqiang] Chongqing Univ, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China; [Zhang, Qianyu] Chongqing Med Univ, Coll Pharm, Mailbox 308, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Zhang, Jinqiang] Chongqing Univ, Sch Pharmaceut Sci, Daxuecheng South Rd 55, Chongqing 401331, Peoples R China"

通信作者："Zhang, QY (通讯作者)，Chongqing Med Univ, Coll Pharm, Mailbox 308, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China.; Zhang, JQ (通讯作者)，Chongqing Univ, Sch Pharmaceut Sci, Daxuecheng South Rd 55, Chongqing 401331, Peoples R China."

来源：NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000880013900007

JCR分区：Q1

影响因子：5.4

年份：2023

卷号：47

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：PASylation; PEGylation; Liposomes; Anti -PEG IgM

摘要："PASylation, which was recently reported as the conjugation of pharmacologically active compounds with polypeptide sequences mainly made of proline, alanine and serine, has been proposed as an alternative to PEGylation. In this study, we designed PAS-modified liposomes (PASylated liposomes) and studied the effect of the incorporation of PAS-lipid on the stability and pharmacokinetic properties of liposomes, and compared them both in vitro and in vivo to PEGylated liposomes. Results showed that PASylated liposomes modified with single-chained PAS-lipid C16-(PA3)7 (SC-PAS-Lip) showed comparable storage and serum stability to PEGylated liposomes (PEG-Lip), and a significantly decreased macrophage uptake compared with unmodified liposomes. SC-PAS-Lip displayed long circulating pharmacokinetic profile which was not impacted by the repeated administration of liposomes, and they were less likely to induce the production of anti-PEG IgM compared with PEGylated liposomes, presenting PASylation as an alternative liposome modification strategy to PEGylation. (c) 2022 Elsevier Inc. All rights reserved."

基金机构：National Natural Science Foundation for Young Scientists of China; Science and Technology Research Program of Chongqing Municipal Education Commission; [81903549]; [KJQN202200451]

基金资助正文：This work was supported by the National Natural Science Foundation for Young Scientists of China (Grant No. 81903549) and Science and Technology Research Program of Chongqing Municipal Education Commission (Grant No. KJQN202200451) .