Imaging mass cytometry: High-dimensional and single-cell perspectives on the microenvironment of solid tumours

作者全名："Liu, Zehan; Xun, Jing; Liu, Shuangqing; Wang, Botao; Zhang, Aimin; Zhang, Lanqiu; Wang, Ximo; Zhang, Qi"

作者地址："[Liu, Zehan; Liu, Shuangqing; Wang, Botao; Zhang, Qi] Tianjin Med Univ, Tianjin Nankai Hosp, Tianjin 300070, Peoples R China; [Liu, Zehan] Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Affiliated Hosp, Dept Gen Surg,Sect HepatoPancreatoBiliary Surg, Chengdu 610031, Peoples R China; [Liu, Zehan] Chongqing Med Univ, Affiliated Hosp Chengdu 2, Chengdu 610031, Peoples R China; [Xun, Jing; Zhang, Lanqiu; Wang, Ximo; Zhang, Qi] Tianjin Med Univ, Nankai Hosp, Tianjin ITCWM Clin Res Ctr, Tianjin Key Lab Acute Abdomen Dis Associated Organ, Tianjin 300100, Peoples R China; [Zhang, Aimin] Tianjin Nankai Hosp, Clin Lab, Tianjin 300100, Peoples R China"

通信作者："Zhang, Q (通讯作者)，Tianjin Med Univ, Tianjin Nankai Hosp, Tianjin 300070, Peoples R China.; Wang, XM; Zhang, Q (通讯作者)，Tianjin Med Univ, Nankai Hosp, Tianjin ITCWM Clin Res Ctr, Tianjin Key Lab Acute Abdomen Dis Associated Organ, Tianjin 300100, Peoples R China."

来源：PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000880418600013

JCR分区：Q3

影响因子：3.8

年份：2022

卷号：175

期号：　

开始页：140

结束页：146

文献类型：Review

关键词：Imaging mass cytometry; Tumour microenvironment; Tumour heterogeneity; Immunotherapy

摘要："Imaging mass cytometry (IMC) is a new technology integrating mass spectrometry, high-resolution laser ablation and immunohistochemistry/cytochemistry. A unique high-dimensional perspective comprehensively and accu-rately depicts the complex interaction of phenotype, signalling pathway and tumour microenvironment and is widely used in solid tumours. However, the application scenarios of IMC in basic medicine and clinical research in solid tumours lack systematic introduction and classification. This paper reviews the application of IMC in depicting the panorama of the tumour microenvironment, revealing tumour spatial heterogeneity, clarifying tumour pharmacological mechanisms, assisting in new drug development, and dynamically evaluating the ef-ficacy of immunotherapy in solid tumours."

基金机构：National Natural Science Foundation of China [81951858]; Tianjin Science and Technology Planning Project [17ZXMFSY00220]; Key Projects of Tianjin Natural Science Foundation [20JCZDJC00780]; Youth Project of Tianjin Health Commission [2021043]; Key Field Project of Traditional Chinese Medicine of Tianjin Health Commission [2020009]; Technology Talent Development Foundation of Tianjin health and Health Committee [KJ20116]; Chengdu High-level Key Clinical Specialty Construction Project and Science

基金资助正文：This study was supported by the National Natural Science Founda-tion of China (81951858) ; Tianjin Science and Technology Planning Project (17ZXMFSY00220) ; Key Projects of Tianjin Natural Science Foundation (20JCZDJC00780) ; Youth Project of Tianjin Health Com-mission (2021043) ; Key Field Project of Traditional Chinese Medicine of Tianjin Health Commission (2020009) ; Technology Talent Development Foundation of Tianjin health and Health Committee (KJ20116) and Chengdu High-level Key Clinical Specialty Construction Project and Science.