Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study

作者全名："Liu, Mengqi; Huang, Yang; Li, Xuemei; Liu, Yang; Yu, Renqiang; Long, Yicheng; Lv, Fajin; Zhou, Xinyu"

作者地址："[Liu, Mengqi; Huang, Yang; Liu, Yang; Yu, Renqiang; Lv, Fajin] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, Chongqing, Peoples R China; [Li, Xuemei; Zhou, Xinyu] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China; [Long, Yicheng] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Peoples R China; [Long, Yicheng] Natl Clin Res Ctr Mental Disorders, Changsha, Peoples R China"

通信作者："Lv, FJ (通讯作者)，Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, Chongqing, Peoples R China.; Zhou, XY (通讯作者)，Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：FRONTIERS IN PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000880851300001

JCR分区：Q2

影响因子：4.7

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：functional MRI; adolescent; female; major depressive disorder; suicidal attempt

摘要："Background: The neurobiological basis of suicidal behaviors among female adolescents with major depressive disorder (MDD) remains largely unclear. Materials and methods: Fifty-eight drug-naive, first-episode female adolescent MDD [including 31 patients with suicidal attempt (SA group) and 27 patients without SA (non-SA group)), and 36 matched healthy controls (HCs) participated in the present study. Resting-state functional magnetic resonance imaging (MR1) was performed on each subject. The metrics of the amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) were compared among the three groups. Then seed-based functional connectivity (FC) was conducted based on the ALFF/fALFF and ReHo results, which were then correlated to clinical variables. Results: Compared with the non-SA group, the SA group exhibited increased fALFF in the bilateral insula and right precentral gyrus, and enhanced ReHo in the left superior temporal gyrus, left middle cingulate cortex, right insula, and right precentral gyrus. Relative to the HCs, the SA group demonstrated additionally reduced fALFF and ReHo in the left middle frontal gyrus. Moreover, the SA group showed increased FC between the right precentral gyrus and the left middle frontal gyrus and left insula, and between the right insula and anterior/middle cingulate cortex compared to the non-SA and HC groups. In addition, the fALFF in the left middle frontal gyrus was positively correlated with the 17-item Hamilton Depression Rating Scale scores, and the values in the fALFF/ReHo in the right insula were positively correlated with the duration of MDD within the patient group. Conclusion: These findings highlight the multiple abnormalities of the frontolimbic circuit, which may enhance our understanding of the neurobiological basis underlying female MDD with SA during adolescence."

基金机构：Chongqing Science and Technology Commission; Chongqing Postdoctoral Special Foundation; Brain Programme Young Scientist Programme; [291 cstc2020jcyj-jqX0024]; [2010010006132663]; [2022ZD0212900]

基金资助正文："Funding This work was supported by the institutional funds from the Chongqing Science and Technology Commission (Grant no. 291 cstc2020jcyj-jqX0024), Chongqing Postdoctoral Special Foundation (Grant no. 2010010006132663), and Brain Programme Young Scientist Programme (Grant no. 2022ZD0212900)."