Effects of Anti-Parkinsonian Drugs on Verbal Fluency in Patients with Parkinson's Disease: A Network Meta-Analysis

作者全名："Zhu, Yuxia; Li, Sichen; Lai, Hongyu; Mo, Lijuan; Tan, Changhong; Liu, Xi; Deng, Fen; Chen, Lifen"

作者地址："[Zhu, Yuxia; Li, Sichen; Lai, Hongyu; Mo, Lijuan; Tan, Changhong; Liu, Xi; Deng, Fen; Chen, Lifen] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, Chongqing 400010, Peoples R China"

通信作者："Deng, F (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, Chongqing 400010, Peoples R China."

来源：BRAIN SCIENCES

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000880935300001

JCR分区：Q3

影响因子：3.3

年份：2022

卷号：12

期号：11

开始页：　

结束页：　

文献类型：Review

关键词：Parkinson's disease; verbal fluency; letter fluency; semantic fluency; drug therapy; network meta-analysis

摘要："Verbal fluency impairment is common in patients with Parkinson's disease (PD), but the effect of drugs on verbal fluency in PD patients has not been comprehensively evaluated. We conducted a network meta-analysis based on four online databases to compare the effect of drugs on verbal fluency in PD patients. This study was performed and reported according to PRISMA-NMA guidelines. In total, 6 out of 3707 articles (three RCTS and three cross-sectional studies) covering eight drug regimens were included (five for letter fluency, five for semantic fluency). In terms of letter fluency, the ranking of the overall efficacy of included drug regimens was: levodopa, levodopa combined with pramipexole, rotigotine, cabergoline, pramipexole, pergolide, but no drug regimen presented a significant advantage over the others. In terms of semantic fluency, the ranking of the overall efficacy of included drug regimens was: rotigotine, levodopa, cabergoline, pergolide, pramipexole, among which, levodopa alone (SMD = 0.93, 95%CI: 0.28-1.59) and rotigotine alone (SMD = 1.18, 95%CI: 0.28-2.09) were statistically superior to pramipexole, while no significant difference was identified between all the other drug regimens. Levodopa and rotigotine seem to be more appropriate choices for PD patients with verbal fluency impairment. Further study is needed to illustrate the efficacy of drugs on verbal fluency in PD patients."

基金机构：National Natural Science Foundation of China [82001367]; Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0180]; Kuanren Talent Program of The Second Affiliated Hospital of Chongqing Medical University

基金资助正文："This research was funded by the National Natural Science Foundation of China [grant number: 82001367, receiver: Xi Liu]; Natural Science Foundation of Chongqing [grant number: cstc2021jcyj-msxmX0180, receiver: Xi Liu]; and Kuanren Talent Program of The Second Affiliated Hospital of Chongqing Medical University [grant number: not applicable, receiver: Xi Liu]."