IL-7: A promising adjuvant ensuring effective T cell responses and memory in combination with cancer vaccines?

作者全名："Zhao, Yue; Wei, Kongyuan; Chi, Hao; Xia, Zhijia; Li, Xiaosong"

作者地址："[Zhao, Yue] Chinese Acad Sci, Canc Hosp Univ Chinese Acad Sci, Zhejiang Canc Hosp, Inst Basic Med & Canc IBMC, Hangzhou, Zhejiang, Peoples R China; [Zhao, Yue; Xia, Zhijia] Ludwig Maximilians Univ Munchen, Dept Gen Visceral & Transplant Surg, Munich, Germany; [Wei, Kongyuan] Heidelberg Univ, Dept Gen Visceral & Transplantat Surg, Heidelberg, Germany; [Chi, Hao] Southwest Med Univ, Clin Med Coll, Luzhou, Peoples R China; [Li, Xiaosong] Chongqing Med Univ, Affiliated Hosp 1, Clin Mol Med Testing Ctr, Chongqing, Peoples R China"

通信作者："Xia, ZJ (通讯作者)，Ludwig Maximilians Univ Munchen, Dept Gen Visceral & Transplant Surg, Munich, Germany.; Li, XS (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Clin Mol Med Testing Ctr, Chongqing, Peoples R China."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000883641900001

JCR分区：Q1

影响因子：7.3

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：IL-7; adjuvant; cancer vaccines; T cell immune response; T cell memory

摘要："Cancer vaccines exhibit specificity, effectiveness, and safety as an alternative immunotherapeutic strategy to struggle against malignant diseases, especially with the rapid development of mRNA cancer vaccines in recent years. However, how to maintain long-term immune memory after vaccination, especially T cells memory, to fulfill lasting surveillance against cancers, is still a challenging issue for researchers all over the world. IL-7 is critical for the development, maintenance, and proliferation of T lymphocytes, highlighting its potential role as an adjuvant in the development of cancer vaccines. Here, we summarized the IL-7/IL-7 receptor signaling in the development of T lymphocytes, the biological function of IL-7 in the maintenance and survival of T lymphocytes, the performance of IL-7 in pre-clinical and clinical trials of cancer vaccines, and the rationale to apply IL-7 as an adjuvant in cancer vaccine-based therapeutic strategy."

基金机构：National Natural Science Foundation of China; Natural Science Foundation of Chongqing; Chongqing Science and Health Joint Medical High-end Talent Project; Science and Technology Research Program of Chongqing Municipal Education Commission; CQMU Program for Youth Innovation in Future Medicine; [81871653]; [cstc2021jsyj-yzysbAX0018]; [2022GDRC012]; [KJZD-K202100402]; [KJQN201900449]; [W0073]

基金资助正文："Funding This study was funded by the National Natural Science Foundation of China (grant number 81871653), the Natural Science Foundation of Chongqing (cstc2021jsyj-yzysbAX0018), Chongqing Science and Health Joint Medical High-end Talent Project (2022GDRC012), Science and Technology Research Program of Chongqing Municipal Education Commission (KJZD-K202100402, KJQN201900449) and CQMU Program for Youth Innovation in Future Medicine (W0073)."