A Systematic Screening of ADHD-Susceptible Variants From 25 Chinese Parents-Offspring Trios

作者全名："Li, Qianqian; Meng, Yingying; Wang, Jingyang; Xie, Yuhang; Li, Tian; Sun, Wei"

作者地址："[Li, Qianqian] Chongqing Med Univ, Affiliated Hosp 2, Dept Psychol Counseling, Chongqing, Peoples R China; [Meng, Yingying; Wang, Jingyang; Xie, Yuhang; Sun, Wei] Nankai Univ, Sch Med, Tianjin, Peoples R China; [Li, Tian] Southwest Univ, State Key Lab Silkworm Genome Biol, Chongqing, Peoples R China"

通信作者："Li, QQ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Psychol Counseling, Chongqing, Peoples R China.; Sun, W (通讯作者)，Nankai Univ, Sch Med, Tianjin, Peoples R China."

来源：FRONTIERS IN GENETICS

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000883988400001

JCR分区：Q2

影响因子：3.7

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：ADHD; WGS; SNV; complex disorders; susceptible

摘要："Attention-deficit/ hyperactivity disorder (ADHD) is one of the most prevalent and heritable childhood behavioral disorders. Although a number of ADHD-susceptible regions had been identified, details about the variations of genes and their related patterns involved in ADHD are still lacking. In this study, we collected 25 Chinese parents-offspring trios, each of which consisted of a child diagnosed with ADHD and his/her unaffected parents, and analyzed the variations from whole-genome sequencing data. SNVs in reported ADHD-susceptible regions and on the genes whose functions were related to dopamine were screened, and we identified a set of variants with functional annotations which were specifically detected in ADHD children, including most SNVs in the gene coding region that might impair protein functions and a few SNVs in promoter or 3' untranslated region (3'-UTR) that might affect the regulation of relative gene expression in a transcriptional or posttranscriptional level. All the information may further contribute to the understanding, prediction, prevention, and treatment of ADHD in clinical."

基金机构：Undergraduate Innovative Research Program of Nankai University [202010055090]

基金资助正文："This work was funded by the Undergraduate Innovative Research Program of Nankai University (project number: 202010055090), and we thank Lanting Guo for kindly providing some of the patient samples."