Macrophage-targeted nanomedicine for the diagnosis and management of atherosclerosis

作者全名："Hu, Ping Ping; Luo, Shuang Xue; Fan, Xiao Qing; Li, Di; Tong, Xiao Yong"

作者地址："[Hu, Ping Ping] Chongqing Med Univ, Coll Pharm, Chongqing Engn Res Ctr Pharmacodynam Evaluat, Chongqing, Peoples R China; [Luo, Shuang Xue; Tong, Xiao Yong] Chongqing Univ, Sch Pharmaceut Sci, Chongqing, Peoples R China; [Fan, Xiao Qing] Army Med Univ, Dept Thorac Surg, Daping Hosp, Chongqing, Peoples R China; [Li, Di] Chongqing Med Univ, Dept Pharm, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Hu, PP (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Engn Res Ctr Pharmacodynam Evaluat, Chongqing, Peoples R China.; Tong, XY (通讯作者)，Chongqing Univ, Sch Pharmaceut Sci, Chongqing, Peoples R China."

来源：FRONTIERS IN PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000884353600001

JCR分区：Q1

影响因子：5.6

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：atherosclerosis; macrophage; nanomedicine; diagnostic imaging; therapeutic

摘要："Atherosclerosis is the primary cause of cardiovascular diseases, such as myocardial infarction and stroke, which account for the highest death toll worldwide. Macrophage is the major contributor to atherosclerosis progression, and therefore, macrophage-associated pathological process is considered an extremely important target for the diagnosis and treatment of atherosclerosis. However, the existing clinical strategies still have many bottlenecks and challenges in atherosclerosis's early detection and management. Nanomedicine, using various nanoparticles/nanocarriers for medical purposes, can effectively load therapeutic agents, significantly improve their stability and accurately deliver them to the atherosclerotic plaques. In this review, we summarized the latest progress of the macrophage-targeted nanomedicine in the diagnosis and treatment of atherosclerosis, and their potential applications and clinical benefits are also discussed."

基金机构：　

基金资助正文：