Does intermittent theta burst stimulation improve working memory capacity? A randomized controlled cross-over experiment

作者全名："Feng, Yali; Zhang, Jack Jiaqi; Zhu, Jiaqi; Tan, Xiaobing; Huang, Sanyue; Bai, Zhongfei; Yin, Ying"

作者地址："[Feng, Yali; Zhu, Jiaqi; Yin, Ying] Chongqing Med Univ, Dept Rehabil Med, Affiliated Hosp 2, Chongqing, Peoples R China; [Zhang, Jack Jiaqi] Hong Kong Polytech Univ, Dept Rehabil Sci, Hong Kong, Peoples R China; [Tan, Xiaobing] Chongqing Med Univ, Dept Rehabil Therapy, Chongqing, Peoples R China; [Huang, Sanyue] Chongqing Med Univ, Clin Coll 2, Off Acad Affairs, Chongqing, Peoples R China; [Bai, Zhongfei] Tongji Univ, Shanghai YangZhi Rehabil Hosp, Sch Med, Dept Rehabil, Shanghai, Peoples R China"

通信作者："Yin, Y (通讯作者)，Chongqing Med Univ, Dept Rehabil Med, Affiliated Hosp 2, Chongqing, Peoples R China."

来源：BEHAVIOURAL BRAIN RESEARCH

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000884693600003

JCR分区：Q2

影响因子：2.7

年份：2023

卷号：436

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Intermittent theta burst stimulation; Working memory; Plasticity; Dorsolateral prefrontal cortex

摘要："Objective: It has been hypothesized that intermittent theta burst stimulation (iTBS) can produce a memoryenhancing effect by inducing long-term potentiation (LTP)-like plasticity in the dorsolateral prefrontal cortex (DLPFC). However, the hemispheric difference by which iTBS modulates working memory in healthy adults has not been well investigated. The objective of the present study is to investigate the effects of iTBS on the left dorsolateral prefrontal cortex (LDLPFC) and right dorsolateral prefrontal cortex (RDLPFC) on working memory performance in healthy adults.Methods: In this randomized cross-over experiment, 31 right-hand dominant healthy adults received a singlesession of iTBS to their LDLPFC, RDLPFC and sham stimulation, in three different visits separated by a sevenday waiting period. Working memory capacity was assessed before and immediately after stimulation, by using 2-and 3-back tasks.Results: After stimulation, significant time effects were found in overall accuracy when performing both 2- (p = 0.013) and 3-back tasks (p = 0.027), as well as the total reaction time during 3-back tasks (p = 0.021). Analysis of secondary outcomes showed an increase in the number of correction rejections in 2-back tasks (p = 0.009). However, all of the time-by-group interaction effects were not significant.Conclusion: This experiment did not find any additional memory-enhancing effects with a single-session of iTBS to either the RDLPFC or the LDLPFC in healthy adults beyond the practice effects."

基金机构：Kuanren Talents Program of the Second Affilated Hospital of Chongqing Medical University [KY2019G009]; Chongqing Medical University Future Medicine Youth Teaching Innovation Team Project [W0001]; Chongqing Science & Technology Bureau and Chongqing Health Commission Joint Medical Research Project [2020MSXM108]

基金资助正文："The work was supported by the Kuanren Talents Program of the Second Affilated Hospital of Chongqing Medical University (No: KY2019G009), Chongqing Medical University Future Medicine Youth Teaching Innovation Team Project (No: W0001), and Chongqing Science & Technology Bureau and Chongqing Health Commission Joint Medical Research Project (2020MSXM108)."