Quercetin Suppresses Human Glioblastoma Migration and Invasion via GSK3 beta/beta-catenin/ZEB1 Signaling Pathway

作者全名："Chen, Bo; Li, Xiaoli; Wu, Lihong; Zhou, Duanfang; Song, Yi; Zhang, Limei; Wu, Qiuya; He, Qichen; Wang, Gang; Liu, Xu; Hu, Hui; Zhou, Weiying"

作者地址："[Chen, Bo; Li, Xiaoli; Wu, Lihong; Zhou, Duanfang; Song, Yi; Zhang, Limei; Wu, Qiuya; He, Qichen; Wang, Gang; Liu, Xu; Hu, Hui; Zhou, Weiying] Chongqing Med Univ, Coll Pharm, Dept Pharmacol, Chongqing, Peoples R China; [Chen, Bo; Li, Xiaoli; Wu, Lihong; Zhou, Duanfang; Song, Yi; Zhang, Limei; Wu, Qiuya; He, Qichen; Wang, Gang; Liu, Xu; Hu, Hui; Zhou, Weiying] Chongqing Med Univ, Chongqing Key Lab Drug Metab, Chongqing, Peoples R China; [Li, Xiaoli; Zhou, Weiying] Chongqing Med Univ, Key Lab Biochem & Mol Pharmacol Chongqing, Chongqing, Peoples R China; [Hu, Hui] Chongqing Med Univ, Chongqing Pharmacodynam Evaluat Engn Technol Res C, Chongqing, Peoples R China"

通信作者："Hu, H; Zhou, WY (通讯作者)，Chongqing Med Univ, Coll Pharm, Dept Pharmacol, Chongqing, Peoples R China.; Hu, H; Zhou, WY (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Drug Metab, Chongqing, Peoples R China.; Zhou, WY (通讯作者)，Chongqing Med Univ, Key Lab Biochem & Mol Pharmacol Chongqing, Chongqing, Peoples R China.; Hu, H (通讯作者)，Chongqing Med Univ, Chongqing Pharmacodynam Evaluat Engn Technol Res C, Chongqing, Peoples R China."

来源：FRONTIERS IN PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000885175600001

JCR分区：Q1

影响因子：5.6

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：quercetin; metastasis; glioblastoma; epithelial-like mesenchymal transition; GSK beta/beta-catenin/ZEB1 signaling

摘要："High invasiveness is a biological and clinical characteristic of glioblastoma and predicts poor prognosis of patients. Quercetin, a natural flavonoid compound, exhibits anticancer activity. However, we have a limited understanding of the possible underlying mechanism of quercetin in glioblastoma. In this study, we investigated the anticancer effect of quercetin in human glioblastoma cells. Our results showed that quercetin markedly suppressed the viability of glioblastoma cells in vitro and in vivo, and significantly inhibited glioblastoma cell migration and invasion. Moreover, quercetin reversed EMT-like mesenchymal phenotype and reduced the expression levels of EMT-related markers. Furthermore, we found that quercetin suppressed GSK-3 beta/beta-catenin/ZEB1 signaling in glioblastoma. Taken together, our results demonstrate that quercetin inhibited migration and invasion of human glioma cells by suppressing GSK3 beta/beta-catenin/ZEB1 signaling. Our study provides evidence that quercetin is a promising therapeutic natural compound to treat glioblastoma."

基金机构：National Natural Science Foundation of China; Basic Research and Frontier Exploration Project of Chongqing Science and Technology Commission; Innovation research group in Colleges and Universities Program of Chongqing Municipal Education Commission; CQMU Program for Youth Innovation in Future Medicine; Top-notch Postgraduate Talent Cultivation program of Chongqing Medical University; [82173869]; [cstc2021ycjh-bgzxm0133]; [CXQT20012]; [W0067]; [BJRC202106]

基金资助正文：Funding This research was funded by the National Natural Science Foundation of China (82173869); Basic Research and Frontier Exploration Project of Chongqing Science and Technology Commission (cstc2021ycjh-bgzxm0133); Innovation research group in Colleges and Universities Program of Chongqing Municipal Education Commission (No. CXQT20012); CQMU Program for Youth Innovation in Future Medicine (W0067); Top-notch Postgraduate Talent Cultivation program of Chongqing Medical University (No. BJRC202106).