Maternal smoking during pregnancy and the risk of congenital urogenital malformations: A systematic review and meta-analysis

作者全名："Zhang, Qiang; Zhang, Zhi-Cheng; He, Xue-Yu; Liu, Zhen-Min; Wei, Guang-Hui; Liu, Xing"

作者地址："[Zhang, Qiang; Zhang, Zhi-Cheng; He, Xue-Yu; Liu, Zhen-Min; Wei, Guang-Hui; Liu, Xing] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Pediat, Minist Educ,Key Lab Child Dev & Disorders,Chongqi, Chongqing, Peoples R China; [Zhang, Qiang; Zhang, Zhi-Cheng; He, Xue-Yu; Liu, Zhen-Min; Wei, Guang-Hui; Liu, Xing] Chongqing Med Univ, Dept Urol, Childrens Hosp, Chongqing, Peoples R China; [Zhang, Qiang; Zhang, Zhi-Cheng; He, Xue-Yu; Liu, Zhen-Min; Wei, Guang-Hui; Liu, Xing] Chongqing Med Univ, Pediat Res Inst, Childrens Hosp, Chongqing, Peoples R China; [Zhang, Qiang; Zhang, Zhi-Cheng; He, Xue-Yu; Liu, Zhen-Min; Wei, Guang-Hui; Liu, Xing] Chongqing Med Univ, Program Youth Innovat Future Med, Chongqing, Peoples R China"

通信作者："Liu, X (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Pediat, Minist Educ,Key Lab Child Dev & Disorders,Chongqi, Chongqing, Peoples R China.; Liu, X (通讯作者)，Chongqing Med Univ, Dept Urol, Childrens Hosp, Chongqing, Peoples R China.; Liu, X (通讯作者)，Chongqing Med Univ, Pediat Res Inst, Childrens Hosp, Chongqing, Peoples R China.; Liu, X (通讯作者)，Chongqing Med Univ, Program Youth Innovat Future Med, Chongqing, Peoples R China."

来源：FRONTIERS IN PEDIATRICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000885418700001

JCR分区：Q1

影响因子：2.6

年份：2022

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：maternal smoking; congenital urogenital malformations; hypospadias; cryptorchidism; meta-analysis; paternal smoking

摘要："Background: Investigations regarding the association between maternal smoking and specific urogenital teratogenesis exist. However, an integrated systematic review and meta-analysis studying the relationship by encompassing the whole urogenital system is essential. Objective: Even though many studies about inborn urogenital malformations have been conducted, its etiologic factors and exact pathogenesis are still unclear. Our aim is to assess the risk of congenital urogenital malformations in offspring of smoking pregnant women. Results: The meta-analysis, covering 41 case-control and 11 cohort studies, suggested that maternal smoking was associated with an increased risk of urogenital teratogenesis (odds ratio [OR] = 1.13, 95% confidence interval [CI]: 1.04-1.23, p = 0.005), cryptorchidism (OR = 1.18, 95%CI: 1.12-1.24, p = 0.0001), hypospadias (OR = 1.16, 95%CI: 1.01-1.33, p = 0.039), and kidney malformations (OR = 1.30, 95%CI: 1.14-1.48, p = 0.0001). Moreover, paternal smoking during the mother's pregnancy was also significantly associated (OR = 1.26, 95%CI: 1.03-1.55, p = 0.028). The association between smoking > 10 cigarettes/day was evident but was not significant (OR = 1.24, 95%CI:0.81-1.88, p = 0.323). Conclusion: Our results showed that maternal smoking during pregnancy increased the risk of congenital urogenital malformations. In numerous epidemiological studies, maternal smoking during pregnancy has a significant role in fetal development. Therefore, quitting tobacco use may be an effective method for reducing the risk of congenital urogenital malformation in pregnant women."

基金机构：National Natural Science Foundation of China [81970571]

基金资助正文：This study was supported by the National Natural Science Foundation of China (No. 81970571).