CD8(+) T-cell immune escape by SARS-CoV-2 variants of concern

作者全名："Kombe Kombe, Arnaud John; Biteghe, Fleury Augustin Nsole; Ndoutoume, Zelia Nelly; Jin, Tengchuan"

作者地址："[Kombe Kombe, Arnaud John; Jin, Tengchuan] Univ Sci & Technol China, Univ Sci & Technol China USTC, Dept Obstet & Gynecol, Div Life Sci & Med,Affiliated Hosp 1, Hefei, Peoples R China; [Biteghe, Fleury Augustin Nsole] Cedars Sinai Med Ctr, Dept Radiat Oncol, Los Angeles, CA USA; [Ndoutoume, Zelia Nelly] Chongqing Med Univ, Clin Sch 2, Med Imaging, Chongqing, Peoples R China; [Jin, Tengchuan] Univ Sci & Technol China, Div Life Sci & Med, Lab Struct Immunol, Chinese Acad Sci Key Lab Innate Immun & Chron Dis, Hefei, Peoples R China; [Jin, Tengchuan] Chinese Acad Sci, Chinese Acad Sci CAS Ctr Excellence Mol Cell Sci, Shanghai, Peoples R China"

通信作者："Jin, TC (通讯作者)，Univ Sci & Technol China, Univ Sci & Technol China USTC, Dept Obstet & Gynecol, Div Life Sci & Med,Affiliated Hosp 1, Hefei, Peoples R China.; Jin, TC (通讯作者)，Univ Sci & Technol China, Div Life Sci & Med, Lab Struct Immunol, Chinese Acad Sci Key Lab Innate Immun & Chron Dis, Hefei, Peoples R China.; Jin, TC (通讯作者)，Chinese Acad Sci, Chinese Acad Sci CAS Ctr Excellence Mol Cell Sci, Shanghai, Peoples R China."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000885589000001

JCR分区：Q1

影响因子：7.3

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：SARS-CoV-2; cellular immunity; CD8+T-cell epitope; cytotoxic T lymphocytes (CTL); variant of concern (VOC); protein mutation; HLA; immune escape

摘要："Despite the efficacy of antiviral drug repositioning, convalescent plasma (CP), and the currently available vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the worldwide coronavirus disease 2019 (COVID-19) pandemic is still challenging because of the ongoing emergence of certain new SARS-CoV-2 strains known as variants of concern (VOCs). Mutations occurring within the viral genome, characterized by these new emerging VOCs, confer on them the ability to efficiently resist and escape natural and vaccine-induced humoral and cellular immune responses. Consequently, these VOCs have enhanced infectivity, increasing their stable spread in a given population with an important fatality rate. While the humoral immune escape process is well documented, the evasion mechanisms of VOCs from cellular immunity are not well elaborated. In this review, we discussed how SARS-CoV-2 VOCs adapt inside host cells and escape anti-COVID-19 cellular immunity, focusing on the effect of specific SARS-CoV-2 mutations in hampering the activation of CD8(+) T-cell immunity."

基金机构：Strategic Priority Research Program of the Chinese Academy of Sciences [XDB29030104]; National Natural Science Fund [31870731]; Fundamental Research Funds for the Central Universities; 100 Talents Programme of The Chinese Academy of Sciences; Chinese National Postdoctorate Subvention; Chinese government scholarship

基金资助正文："TJ is supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDB29030104), the National Natural Science Fund (Grant No.: 31870731), the Fundamental Research Funds for the Central Universities, and the 100 Talents Programme of The Chinese Academy of Sciences. AK is supported by the Chinese National Postdoctorate Subvention. ZNN is supported by a Chinese government scholarship."