Low and high dose methamphetamine differentially regulate synaptic structural plasticity in cortex and hippocampus

作者全名："Ding, Jiuyang; Huang, Jian; Tang, Xiang; Shen, Lingyi; Hu, Shanshan; He, Jiaojiao; Liu, Ting; Yu, Zhixing; Liu, Yubo; Wang, Qiyan; Wang, Jiawen; Zhao, Na; Qi, Xiaolan; Huang, Jiang"

作者地址："[Ding, Jiuyang; Yu, Zhixing; Liu, Yubo; Wang, Qiyan; Wang, Jiawen; Zhao, Na; Huang, Jiang] Guizhou Med Univ, Sch Forens Med, Guiyang, Peoples R China; [Ding, Jiuyang; Qi, Xiaolan] Guizhou Med Univ, Key Lab Endem & Ethn Dis, Minist Educ, Guiyang, Peoples R China; [Huang, Jian] Southern Med Univ, Sch Forens Med, Guangzhou Key Lab Forens Multiom Precis Identifica, Guangzhou, Peoples R China; [Tang, Xiang] Chongqing Med Univ, Dept Children Rehabil, Childrens Hosp, Chongqing, Peoples R China; [Tang, Xiang] Chongqing Med Univ, Key Lab Child Dev & Disorders, Minist Educ, Childrens Hosp, Chongqing, Peoples R China; [Tang, Xiang] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Childrens Hosp, Chongqing, Peoples R China; [Tang, Xiang] Chongqing Med Univ, China Int Sci & Technol Cooperat Base Child Dev &, Childrens Hosp, Chongqing, Peoples R China; [Tang, Xiang] Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Pediat, Chongqing, Peoples R China; [Shen, Lingyi] Guizhou Med Univ, Sch Basic Med Sci, Guiyang, Peoples R China; [Hu, Shanshan] Zunyi Med Univ, Affiliated Hosp, Good Clin Practice Ctr, Zunyi, Peoples R China; [He, Jiaojiao] Guizhou Med Univ, Sch Publ Hlth, Key Lab Environm Pollut Monitoring & Dis Control, Minist Educ, Guiyang, Peoples R China; [Liu, Ting] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Key Lab Pharmaceut Guizhou Prov, Guiyang, Peoples R China"

通信作者："Ding, JY; Huang, J (通讯作者)，Guizhou Med Univ, Sch Forens Med, Guiyang, Peoples R China.; Ding, JY (通讯作者)，Guizhou Med Univ, Key Lab Endem & Ethn Dis, Minist Educ, Guiyang, Peoples R China."

来源：FRONTIERS IN CELLULAR NEUROSCIENCE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000885600400001

JCR分区：Q2

影响因子：5.3

年份：2022

卷号：16

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：synapse; structural plasticity; prefrontal cortex; hippocampus; methamphetamine

摘要："Psychostimulants, such as methamphetamine (METH) can induce structural remodeling of synapses by remodeling presynaptic and postsynaptic morphology. Escalating or long-lasting high dose METH accounts for neurodegeneration by targeting multiple neurotransmitters. However, the effects of low dose METH on synaptic structure and the modulation mechanism remain elusive. This study aims to assess the effects of low dose (2 mg/kg) and high dose (10 mg/kg) of METH on synaptic structure alternation in hippocampus and prefrontal cortex (PFC) and to reveal the underlying mechanism involved in the process. Low dose METH promoted spine formation, synaptic number increase, post-synaptic density length elongation, and memory function. High dose of METH induced synaptic degeneration, neuronal number loss and memory impairment. Moreover, high dose, but not low dose, of METH caused gliosis in PFC and hippocampus. Mechanism-wise, low dose METH inactivated ras-related C3 botulinum toxin substrate 1 (Rac1) and activated cell division control protein 42 homolog (Cdc42); whereas high dose METH inactivated Cdc42 and activated Rac1. We provided evidence that low and high doses of METH differentially regulate synaptic plasticity in cortex and hippocampus."

基金机构："Research Foundation for Advanced Talents of Guizhou Medical University [University Contract of Doctors J [2021] 014]; Natural Science Foundation of Guizhou Medical University Incubation Program [20NSP084]; National Key Research and Development Program of China [2022YFC2600831]; Guizhou Province Engineering Technology Research Centre Project (Qian High-Tech of Development and Reform Commission) [[2016]1345]; Guizhou Scientific Support Project [Qian Science Support [2019] 2825, Qian Science Support [2020] 4Y057]; Guizhou ""Hundred"" innovative talents project [Qian Science Talent Platform [2020] 6012]; Guizhou Science Project [Qian Science Foundation [2020] 1Y353]; Guizhou science and technology cooperation platform talent project [[2018] 5779-3]"

基金资助正文："This work was supported by Research Foundation for Advanced Talents of Guizhou Medical University (Grant No. University Contract of Doctors J [2021] 014), Natural Science Foundation of Guizhou Medical University Incubation Program (Grant No. 20NSP084) (to JD), National Key Research and Development Program of China (Sub-project, 2022YFC2600831), Guizhou Province Engineering Technology Research Centre Project (Qian High-Tech of Development and Reform Commission No. [2016]1345), Guizhou Scientific Support Project (Qian Science Support [2019] 2825), Guizhou ""Hundred"" innovative talents project (Qian Science Talent Platform [2020] 6012), Guizhou Scientific Support Project (Qian Science Support [2020] 4Y057), Guizhou Science Project (Qian Science Foundation [2020] 1Y353) (to JHu), and Guizhou science and technology cooperation platform talent project ([2018] 5779-3) (to JW)."