Circulating soluble CD36 as a novel biomarker for progression and prognosis of HBV-related liver diseases

作者全名："Cai, Chunxian; Xiao, Anhua; Luo, Xiaoqing; Zheng, Enze; Li, Yiyu; Lei, Yu; Zhong, Shan; Chen, Yaxi; Yang, Ping; Tang, Zhurong; Zhou, Zhi"

作者地址："[Cai, Chunxian; Lei, Yu; Zhong, Shan; Zhou, Zhi] Chongqing Med Univ, Affiliated Hosp 2, Dept Infect Dis, Chongqing, Peoples R China; [Xiao, Anhua; Luo, Xiaoqing; Zheng, Enze; Li, Yiyu; Chen, Yaxi; Yang, Ping] Chongqing Med Univ, Ctr Lipid Res, Key Lab Mol Biol Infect Dis, Minist Educ, Chongqing, Peoples R China; [Tang, Zhurong] Chongqing Med Univ, Inst Life Sci, Chongqing, Peoples R China"

通信作者："Zhou, Z (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Infect Dis, Chongqing, Peoples R China.; Yang, P (通讯作者)，Chongqing Med Univ, Ctr Lipid Res, Key Lab Mol Biol Infect Dis, Minist Educ, Chongqing, Peoples R China.; Tang, ZR (通讯作者)，Chongqing Med Univ, Inst Life Sci, Chongqing, Peoples R China."

来源：FRONTIERS IN MICROBIOLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:000885618900001

JCR分区：Q2

影响因子：5.2

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：sCD36; biomarker; HBV-related liver diseases; cirrhosis; liver failure

摘要："BackgroundOur previous study suggested CD36 may be a positive regulator of hepatitis B virus (HBV) replication in vitro. Therefore, the present study aimed to investigate whether circulating soluble CD36 (sCD36) could serve as a diagnostic and prognostic biomarker for HBV-related liver diseases based on the clinic collected data. MethodsA total of 282 subjects were divided into healthy controls (HC, n = 47), chronic hepatitis B (CHB, n = 68), HBV-related liver cirrhosis (HBV-LC, n = 167). Soluble CD36 in plasma was measured by ELISA, and monocyte or platelet CD36 expression was determined by flow cytometry. ResultsThere was a step-wise increase of sCD36 with the progression of chronic HBV infection, and it was the highest in the HBV- LC group with liver failure (1.50, IQR:1.04-2.00) as compared with HC (0.38, IQR:0.27-0.38), CHB (0.75, IQR:0.40-1.13), and HBV-LC without liver failure (1.02, IQR,0.61-1.35) group. Circulating sCD36 was not correlated with serum HBV DNA levels, but correlated with liver function parameters. Additionally, ROC analysis confirmed sCD36 could be used to predict liver failure for HBV-LC patients, which yielded an AUC of 0.775 with 71.0% sensitivity and 72.2% specificity. Multivariate logistic regression analysis revealed sCD36 is an independent risk factor in predicting liver failure. Moreover, plasma sCD36 in HBV-LC patients was significantly correlated with prognostic indices, including MELD, MELD-Na and CHILD-PUGH scores. On the other hand, CD36 expression on monocytes or platelets was positively correlated with plasma sCD36 levels, whereas they were not strongly associated with the disease severity. ConclusionCirculating sCD36 could be used as a novel noninvasive biomarker for predicting liver failure and prognosis in chronic HBV infected patients."

基金机构：National Natural Science Foundation of China; General Program of Chongqing Natural Science Foundation; Chongqing Research Program of Basic Research and Frontier Technology; [82202712]; [cstc2021jcyj-msxmX0061]; [cstc2020jcyj-msxmX0205]

基金资助正文："Funding This research was supported by the National Natural Science Foundation of China (82202712), the General Program of Chongqing Natural Science Foundation (cstc2021jcyj-msxmX0061), the Chongqing Research Program of Basic Research and Frontier Technology (cstc2020jcyj-msxmX0205)."