Carbon dots based on endogenous nutrients with visible and NIR fluorescence to penetrate blood-brain barrier

作者全名："Yang, Shiyu; Chen, Zhiqiong; Zhou, Ping; Xia, Jiashan; Deng, Tao; Yu, Chao"

作者地址："[Yang, Shiyu; Chen, Zhiqiong; Zhou, Ping; Xia, Jiashan; Deng, Tao; Yu, Chao] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China; [Yang, Shiyu; Xia, Jiashan; Deng, Tao; Yu, Chao] Chongqing Pharmacodynam Evaluat Engn Technol Res C, Chongqing 400016, Peoples R China; [Zhou, Ping; Deng, Tao; Yu, Chao] Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400016, Peoples R China"

通信作者："Deng, T; Yu, C (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China."

来源：CARBON

ESI学科分类：CHEMISTRY

WOS号：WOS:000886521900001

JCR分区：Q1

影响因子：10.9

年份：2023

卷号：202

期号：　

开始页：130

结束页：140

文献类型：Article

关键词：Brain diseases; Blood brain barrier; Multi -emission fluorescence; Carbon dots; Theranostics

摘要："Compared with visible fluorescence carbon dots (CDs), the multi-emission (visible and near infrared) fluores-cence CDs based platform (V-N Platform) with blood-brain barrier penetration, real-time brain imaging and drug loading capacities, is of great significance. Herein, a novel type of multi-emission fluorescence CDs (GT) was created to penetrate BBB for brain imaging and local drug delivery, which was synthesized by hydrothermal method, using endogenous L-tryptophan and D-glucose. The capability for in vitro imaging was verified through the experiments on cell imaging. Moreover, the ability of in vivo imaging, especially for brain imaging, was confirmed by experiments in mice and zebrafish. In addition, the in vitro and in vivo experiments preliminarily confirmed its potential to act as a drug delivery platform. This V-N Platform (GT) will be expected to have a significant impact on the researches for CDs and the theranostics of brain diseases."

基金机构：Future Medical Youth Innovation Team Support Program of Chongqing Medical University [W0090]; esearch Center of Pharmaceutical Preparations and Nanomedicine and Chongqing Key Laboratory for Pharmaceutical Metabolism Research of Chongqing Medical University

基金资助正文：This work was financially supported by Future Medical Youth Innovation Team Support Program of Chongqing Medical University (W0090) . We sincerely thank Research Center of Pharmaceutical Preparations and Nanomedicine and Chongqing Key Laboratory for Pharmaceutical Metabolism Research of Chongqing Medical University for the support of the work.