Effectiveness of silver dressings in the treatment of diabetic foot ulcers: a systematic review and meta-analysis
作者全名："Luo, YiXin; Li, Li; Zhao, Ping; Yang, Chuan; Zhang, June"
作者地址："[Luo, YiXin; Zhang, June] Sun Yat Sen Univ, Sch Nursing, Guangzhou, Peoples R China; [Li, Li] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Emergency Dept, Guangzhou, Peoples R China; [Zhao, Ping] Chongqing Med Univ, Dept Nephrol, Bishan Hosp, Chongqing, Peoples R China; [Yang, Chuan] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Endocrinol, Guangzhou, Peoples R China"
通信作者："Zhang, JN (通讯作者)，Sun Yat Sen Univ, Sch Nursing, Guangzhou, Peoples R China.; Yang, C (通讯作者)，Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Endocrinol, Guangzhou, Peoples R China."
来源：JOURNAL OF WOUND CARE
ESI学科分类：CLINICAL MEDICINE
WOS号：WOS:000886944800010
JCR分区：Q2
影响因子：1.9
年份：2022
卷号：31
期号：11
开始页：979
结束页：986
文献类型：Review
关键词：diabetes; diabetic foot ulcers; foot; meta-analysis; silver dressing; ulcer; wound; wound care; wound dressing; wound healing
摘要："Objective: Silver dressings have been used in the treatment of diabetic foot ulcers (DFUs). However, meta-analyses examining their effectiveness is lacking. Therefore, this meta-analysis evaluates the effectiveness of silver dressings on DFU healing. Method: Various databases were searched for randomised controlled trials (RCTs) of silver dressing applied to DFUs. Results: A total of seven studies involving 650 patients were identified for inclusion in the meta-analysis. The odds ratio (OR) for silver dressing improving wound healing rate, complete healing time, ulcer-related in-hospital time and infection resolution rate were: 4.02 (95% confidence interval [CI]: 2.25-7.17; p<0.01); 2.81 (95% CI: -3.33--2.29; p<0.01); 12.13 (95% CI:-20.64--3.62; p<0.01); and 7.36 (95% CI: 1.58-34.22; p=0.01), respectively. The OR on ulcer area reduction was 8.60 (95% CI:-8.93-26.12; p=0.34) indicating no significant effect. Conclusion: The results of this meta-analysis showed that silver dressings enhance DFU healing rate, shorten the time to complete healing, shorten in-hospital duration, and improve infection resolution rate, while having no significant effect on reduction of ulcer area. Large-scale, multicentre, rigorously designed RCTs are recommended for future investigation to justify the beneficial effects of silver dressings on DFU healing."
基金机构：National Natural Science Foundation of China [81670764]; Guangdong Basic and Applied Basic Research Foundation [2020B1515120076]
基金资助正文：This work was supported by grants from the National Natural Science Foundation of China (81670764) and Guangdong Basic and Applied Basic Research Foundation (2020B1515120076). The authors have no conflicts of interest.
