Brain white matter microstructure abnormalities in children with optimal outcome from autism: a four-year follow-up study

作者全名："Zhang, Manxue; Hu, Xiao; Jiao, Jian; Yuan, Danfeng; Li, Sixun; Luo, Tingting; Wang, Meiwen; Situ, Mingjing; Sun, Xueli; Huang, Yi"

作者地址："[Zhang, Manxue; Hu, Xiao; Jiao, Jian; Yuan, Danfeng; Li, Sixun; Luo, Tingting; Wang, Meiwen; Situ, Mingjing; Sun, Xueli; Huang, Yi] Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu, Peoples R China; [Zhang, Manxue] Chongqing Med Univ, Affiliated Hosp 2, Chongqing, Peoples R China; [Hu, Xiao] Sichuan Univ, West China Hosp 2, Chengdu, Peoples R China; [Huang, Yi] Sichuan Univ, West China Hosp, Brain Res Ctr, Chengdu, Peoples R China"

通信作者："Sun, XL; Huang, Y (通讯作者)，Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu, Peoples R China.; Huang, Y (通讯作者)，Sichuan Univ, West China Hosp, Brain Res Ctr, Chengdu, Peoples R China."

来源：SCIENTIFIC REPORTS

ESI学科分类：Multidisciplinary

WOS号：WOS:000887936300018

JCR分区：Q1

影响因子：4.6

年份：2022

卷号：12

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder, with only a small proportion of people obtaining optimal outcomes. We do not know if children with ASD exhibit abnormalities in the white matter (WM) microstructure or if this pattern would predict ASD prognosis in a longitudinal study. 182 children with ASD were recruited for MRI and clinical assessment; 111 completed a four-year follow-up visit (30 with optimal outcomes, ASD-; 81 with persistent diagnosis, ASD+). Additionally, 72 typically developing controls (TDC) were recruited. The microstructural integrity of WM fiber tracts was revealed using tract-based spatial statistics (TBSS) and probabilistic tractography analyses. We examined the neuroimaging abnormality associated with ASD and its relationship to ASD with optimal outcome. The ASD+ and TDC groups were propensity score matched to the ASD- group in terms of age, gender, and IQ. TBSS indicated that children with ASD exhibited abnormalities in the superior longitudinal fasciculus (SLF), inferior longitudinal fasciculus (ILF), and extending to the anterior thalamic radiation (ATR) and cingulum; whereas the ASD+ group showed more severe abnormalities than the ASD- group. Probabilistic tractography analysis revealed that ASD+ group exhibited lower Fractional Anisotropy (FA) of the left superior thalamic radiation (STR L) than ASD- group, and that FA value of the STR L was a significant predictor of optimal outcome (EX(B), 6.25; 95% CI 2.50-15.63; p < 0.001). Children with ASD showed significant variations in SLF_L and STR_L, and STR_L was a predictor of 'ASD with optimal outcome'. Our findings may aid in comprehension of the mechanisms of 'ASD with optimal outcome'."

基金机构：National Key Research& Development Program of China [2016YFC1306104]; National Natural Science Foundation of China [81371495]; Sichuan Province Science and Technology Support Program [2020YFH0049]

基金资助正文：This work was supported by the National Key Research& Development Program of China (NO. 2016YFC1306104). It provided the fund for the investigation. This work was supported by the National Natural Science Foundation of China (NO. 81371495). It provided the fund for the investigation. This work was also supported by the Sichuan Province Science and Technology Support Program (NO. 2020YFH0049). It provided the fund for editing and the subject's allowance.