Differential diagnosis of benign and malignant patchy ground-glass opacity by thin-section computed tomography

作者全名："Liang, Zhang-Rui; Ye, Min; Lv, Fa-Jin; Fu, Bin-Jie; Lin, Rui-Yu; Li, Wang-Jia; Chu, Zhi-Gang"

作者地址："[Liang, Zhang-Rui; Ye, Min; Lv, Fa-Jin; Fu, Bin-Jie; Lin, Rui-Yu; Li, Wang-Jia; Chu, Zhi-Gang] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing, Peoples R China"

通信作者："Chu, ZG (通讯作者)，Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing, Peoples R China."

来源：BMC CANCER

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000887938400001

JCR分区：Q2

影响因子：3.8

年份：2022

卷号：22

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Benign; Ground-glass opacity; Malignancy; X-ray computed; Tomography

摘要："Background Previous studies confirmed that ground-glass nodules (GGNs) with certain CT manifestations had a higher probability of malignancy. However, differentiating patchy ground-glass opacities (GGOs) and GGNs has not been discussed solely. This study aimed to investigate the differences between the CT features of benign and malignant patchy GGOs to improve the differential diagnosis. Methods From January 2016 to September 2021, 226 patients with 247 patchy GGOs (103 benign and 144 malignant) confirmed by postoperative pathological examination or follow-up were retrospectively enrolled. Their clinical and CT data were reviewed, and their CT features were compared. A binary logistic regression analysis was performed to reveal the predictors of malignancy. Results Compared to patients with benign patchy GGOs, malignant cases were older (P < 0.001), had a lower incidence of malignant tumor history (P = 0.003), and more commonly occurred in females (P = 0.012). Based on CT images, there were significant differences in the location, distribution, density pattern, internal bronchial changes, and boundary between malignant and benign GGOs (P < 0.05). The binary logistic regression analysis revealed that the independent predictors of malignant GGOs were the following: patient age >= 58 years [odds ratio (OR), 2.175; 95% confidence interval (CI), 1.135-6.496; P = 0.025], locating in the upper lobe (OR, 5.481; 95%CI, 2.027-14.818; P = 0.001), distributing along the bronchovascular bundles (OR, 12.770; 95%CI, 4.062-40.145; P < 0.001), centrally distributed solid component (OR, 3.024; 95%CI, 1.124-8.133; P = 0.028), and well-defined boundary (OR, 5.094; 95%CI, 2.079-12.482; P < 0.001). Conclusions In older patients (>= 58 years), well-defined patchy GGOs with centric solid component, locating in the upper lobe, and distributing along the bronchovascular bundles should be highly suspected as malignancy."

基金机构：Joint Project Chongqing Science and Technology Commission; Chongqing Public Health Commission [2022MSXM050]

基金资助正文：This study was supported by the Joint Project Chongqing Science and Technology Commission and Chongqing Public Health Commission (2022MSXM050).