Effect of I-131 with and without artificial liver support system in patients with Graves' disease and severe liver dysfunction: A retrospective study

作者全名："Rao, Maohua; Wang, Yirui; Ren, Jianli; Chen, Yue; Zheng, Chenxi; Xiong, Yalan; Yan, Qingbo; Li, Shiying; Yuan, Gengbiao"

作者地址："[Rao, Maohua; Wang, Yirui; Zheng, Chenxi; Xiong, Yalan; Yan, Qingbo; Yuan, Gengbiao] Chongqing Med Univ, Affiliated Hosp 2, Dept Nucl Med, Chongqing, Peoples R China; [Ren, Jianli] Chongqing Med Univ, Affiliated Hosp 2, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing, Peoples R China; [Chen, Yue] Nucl Med & Mol Imaging Key Lab Sichuan Prov, Luzhou, Peoples R China; [Li, Shiying] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, Chongqing, Peoples R China"

通信作者："Yuan, GB (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Nucl Med, Chongqing, Peoples R China.; Li, SY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, Chongqing, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000888187000001

JCR分区：Q2

影响因子：5.2

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：thyroid; severe liver dysfunction; artificial liver support system; radioiodine; therapeutics

摘要："ObjectiveTreatment decision-making in Graves' disease (GD) with severe liver dysfunction (LD) is a clinical challenge. This research was carried out to evaluate the effect of radioiodine (I-131) with or without an artificial liver support system (ALSS) in GD patients with severe LD. MethodsIn total, 45 patients diagnosed with GD and severe LD were enrolled and allocated to two groups: patients treated with I-131 alone (n=30) (Group A)and patients by a combination of I-131 and ALSS (n=15)(Group B). Liver function, thyroid hormone concentrations, therapeutic efficacy, and the cost of treatment were compared between the two groups. ResultsThyroid hormone concentrations were lower 2 weeks after I-131 treatment, but no deterioration in liver function was identified. There was no statistically significant difference in the treatment efficacy between the two groups. The hospital stay, total cost, and daily cost were lower in patients treated with I-131 alone than in those treated with I-131 and an ALSS (p<0.05). ConclusionThe key point of treating GD patients with severe LD is to control the GD.I-131 is recommended as an effective and safe and should be applied as soon as possible once the diagnosis is clarified; however, when used in combination with an ALSS, there was no substantial improvement in therapeutic efficacy."

基金机构："high-level Medical Reserved Personnel Training Project of Chongqing, a Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University [KR2019G001]; Chongqing Science and Health Joint Medical Research Project-Young, a Middle-aged High-level Talent Project [2020GDRC011]; Open Project Program of Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province [HYX20001]; National Natural Science Foundation of China Youth Fund [81801990]"

基金资助正文："This work was supported by a high-level Medical Reserved Personnel Training Project of Chongqing, a Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University (KR2019G001), a Chongqing Science and Health Joint Medical Research Project-Young, a Middle-aged High-level Talent Project (2020GDRC011), an Open Project Program of Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province (HYX20001), and a National Natural Science Foundation of China Youth Fund (81801990). The funding bodies had no involvement in the study design; data collection, analysis, or interpretation; writing of the manuscript; or decision to publish."