Transplacental transmission of SARS-CoV-2 immunoglobulin G antibody to infants from maternal COVID-19 vaccine immunization before pregnancy

作者全名："Yang, Yuting; Xing, Huiwu; Zhao, Yao"

作者地址："[Yang, Yuting; Xing, Huiwu; Zhao, Yao] Chongqing Med Univ, Pediat Res Inst, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ Key Lab Child Dev & Disorders,Chongqin, Chongqing, Peoples R China; [Zhao, Yao] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ Key Lab Child Dev & Disorders, Chongqing Key Lab ChildInfect & Immun,Childrens Ho, Chongqing 400014, Peoples R China"

通信作者："Zhao, Y (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Minist Educ Key Lab Child Dev & Disorders, Chongqing Key Lab ChildInfect & Immun,Childrens Ho, Chongqing 400014, Peoples R China."

来源：JOURNAL OF MEDICAL VIROLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:000888919900001

JCR分区：Q1

影响因子：12.7

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：coronavirus; disease control; SARS coronavirus; virus classification; vaccines; vaccine strains

摘要："The coronavirus disease 2019 (COVID-19) vaccine generates functional antibodies in maternal circulation that are detectable in infants, while the information is restricted to the usage of COVID-19 vaccine during pregnancy. In this study, we aimed to evaluate the effect of maternal COVID-19 vaccines before pregnancy. Infants were included from mothers with no inactivated COVID-19 vaccine, 1-, 2-, and 3-dose before pregnancy, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) antibodies were tested. Comparative analysis was done between the groups. A total of 130 infants were enrolled in the study. Significantly higher levels of SARS-CoV-2 IgG antibodies in infants born to mothers with 3-dose COVID-19 vaccine before pregnancy compared with 1- and 2-dose groups (p < 0.0001). The levels of antibodies decreased significantly with age in infants born to mothers with the 3-dose COVID-19 vaccine before pregnancy (r = -0.338, p = 0.035), and it was still higher than that 2-dose COVID-19 vaccine group. The maternal SARS-CoV-2 antibodies produced from the inactivated COVID-19 vaccine before pregnancy can be transferred to newborns via the placenta. Maternal immunization with 3-dose of the COVID-19 vaccine before pregnancy could be more beneficial for both mothers and infants."

基金机构："National Clinical Research Center for Child Health and Disorders General Project and Youth Project [NCRCCHD-2019-GP-04/No.NCRCCHD-2021-YP-03]; Chongqing Talent Program [CQYC20210303393]; Program for Youth Innovation in Future Medicine, Chongqing Medical University"

基金资助正文："National Clinical Research Center for Child Health and Disorders General Project and Youth Project, Grant/Award Number:No.NCRCCHD-2019-GP-04/No.NCRCCHD-2021-YP-03; Chongqing Talent Program, Grant/Award Number: CQYC20210303393; Program for Youth Innovation in Future Medicine, Chongqing Medical University"