Visualization system based on hierarchical targeting for diagnosis and treatment of hepatocellular carcinoma

作者全名："Shi, Shasha; Li, Huipu; Zheng, Xi; Lv, Lin; Liao, Shengtao; Lu, Peng; Liu, Maoxia; Zhao, Hongyun; Mei, Zhechuan"

作者地址："[Shi, Shasha; Lv, Lin; Liao, Shengtao; Zhao, Hongyun; Mei, Zhechuan] Second Affiliated Hosp Chongqing Med Univ, Dept Gastroenterol, Chongqing 400010, Peoples R China; [Shi, Shasha; Zhao, Hongyun] Second Affiliated Hosp Chongqing Med Univ, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400016, Peoples R China; [Li, Huipu] Chongqing Hosp Tradit Chinese Med, Dept Gastroenterol, Chongqing 400020, Peoples R China; [Zheng, Xi] Chongqing Univ Canc Hosp, Dept Gastroenterol, Chongqing 400030, Peoples R China; [Shi, Shasha] Third Hosp Mianyang, Sichuan Mental Hlth Ctr, Dept Gastroenterol, Mianyang 621000, Peoples R China; [Lu, Peng] Third Hosp Mianyang, Sichuan Mental Hlth Ctr, Second Dept Geriatr, Mianyang 621000, Peoples R China; [Liu, Maoxia] Chongqing Univ Cent Hosp, Chongqing Emergency Med Ctr, Outpatient Dept, Chongqing 400030, Peoples R China"

通信作者："Zhao, H; Mei, Z (通讯作者)，Second Affiliated Hosp Chongqing Med Univ, Dept Gastroenterol, Chongqing 400010, Peoples R China."

来源：MATERIALS TODAY BIO

ESI学科分类：　

WOS号：WOS:000890622700002

JCR分区：Q1

影响因子：8.2

年份：2022

卷号：16

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Visual system; Hierarchical targeting; Magnet; Hepatocellular carcinoma

摘要："The accuracy and enrichment rate of targeted drugs largely determine the clinical diagnosis and treatment effect. Therefore, the accuracy and enrichment rate of targeted drugs should be improved. We designed a visual diagnosis and treatment system based on hierarchical targeting. It consists of multifunctional magnetic nanoparticles and a bio magnetic material. Bio-magnet mediated primary targeting can effectively improve the drug enrichment rate in the target tissue. SNF peptide/epithelial cell adhesion molecule antibody mediated targeting liver cancer stem cells (LCSCs) (secondary target) can improve the accuracy of the treatment and its outcomes. Low intensity focused ultrasound irradiation can explode nanoparticles around LCSCs, which can cause physical damage to cells. The combination of released interferon gamma and its receptor (tertiary target) can be used to initiate chemotherapy and immunotherapy. Using the optical properties of Fe3O4 and the phase transformation ability of perfluoropentane, the system can enhance photoacoustic and ultrasonic molecular imaging enabling diagnosis and treatment visualization. Targeting LCSCs can accurately provide physical, chemical, and immune treatment of Hepatocellular carcinoma, making the therapeutic effect more effective and thorough. This system may provide a new method for a more accurate visual diagnosis and treatment of tumors."

基金机构："National Natural Science Foundation of China [82173360]; National Natural Science Foundation Youth Project [81801714]; Senior Medical Talents Program of Chongqing for Yong and Middle-aged [11-020]; Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University [2021240308, 13-003-023]"

基金资助正文："This work was financially supported by National Natural Science Foundation of China (No. 82173360); National Natural Science Foundation Youth Project (No. 81801714); Senior Medical Talents Program of Chongqing for Yong and Middle-aged (No. 11-020); Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University (No. 2021240308, 13-003-023)."